Department of Community Health Nursing, Razi Faculty of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran.
Department of Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
BMC Womens Health. 2022 Nov 4;22(1):431. doi: 10.1186/s12905-022-02024-1.
Urinary incontinence, especially stress urinary incontinence (SUI), is one of the problems experienced by premenopausal women. Given the role of vitamin D in enhancing muscle strength and function, this study explored the effect of vitamin D3 supplementation on SUI in premenopausal women.
A randomized controlled trial was performed with 60 premenopausal women referring to Kerman gynecological clinic in 2020 and 2021. Eligible women received a 5000-unit vitamin D supplement or placebo weekly for 3 months. The International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-SF) was utilized to assess SUI severity before and after the intervention. The t-test, Chi-square test, and repeated measures ANOVA were carried out in SPSS software (version 22) to analyze the data. P-values smaller than 0.05 were considered significant.
Before the intervention, there was no significant difference between the intervention and control groups in SUI severity (P = 0.652) and the impact of SUI severity on premenopausal women's lives (P = 0.804). In contrast, after 8-12 weeks of vitamin D supplementation, these scores decreased significantly in the intervention group relative to the control group (P < 0.001). In addition, after vitamin D supplementation, the number of SUI and urinary leakage symptoms decreased in the intervention group (P < 0.001).
Vitamin D supplementation improves SUI in premenopausal women.
This trial was registered with the Iranian Registry of Clinical Trials; https://fa.irct.ir/trial/53474 (IRCT20190724044318N2) on 11/02/2021.
尿失禁，特别是压力性尿失禁（SUI），是绝经前女性面临的问题之一。鉴于维生素 D 对增强肌肉力量和功能的作用，本研究探讨了维生素 D3 补充剂对绝经前女性 SUI 的影响。
2020 年至 2021 年，对 60 名前往克尔曼妇科诊所就诊的绝经前女性进行了一项随机对照试验。符合条件的女性每周接受 5000 单位维生素 D 补充剂或安慰剂治疗 3 个月。采用国际尿失禁咨询问卷-尿失禁简短问卷（ICIQ-SF）评估干预前后 SUI 的严重程度。采用 SPSS 软件（版本 22）进行 t 检验、卡方检验和重复测量方差分析来分析数据。P 值小于 0.05 被认为具有统计学意义。
干预前，干预组和对照组在 SUI 严重程度（P=0.652）和 SUI 严重程度对绝经前女性生活的影响（P=0.804）方面无显著差异。相比之下，在接受 8-12 周的维生素 D 补充后，干预组的这些评分与对照组相比显著降低（P＜0.001）。此外，在接受维生素 D 补充后，干预组的 SUI 和尿漏症状数量减少（P＜0.001）。
维生素 D 补充可改善绝经前女性的 SUI。
本试验在伊朗临床试验注册中心注册；https://fa.irct.ir/trial/53474（IRCT20190724044318N2），注册日期为 2021 年 2 月 11 日。
