Katic Josip, Jurisic Zrinka, Kumric Marko, Borovac Josip A, Anic Ante, Breskovic Toni, Supe-Domic Daniela, Bozic Josko
Department of Cardiology, University Hospital of Split, 21000 Split, Croatia.
Department of Internal Medicine, University of Split School of Medicine, 21000 Split, Croatia.
J Cardiovasc Dev Dis. 2023 Feb 17;10(2):85. doi: 10.3390/jcdd10020085.
The autonomic nervous system is crucial in initiating and maintaining atrial fibrillation (AF). Catestatin is a multipurpose peptide that regulates cardiovascular systems and reduces harmful, excessive activity of the sympathetic nervous system by blocking the release of catecholamines. We aimed to determine whether serum catestatin concentrations are associated with AF severity, duration indices, and various clinical and laboratory indicators in these individuals to better define the clinical value of catestatin in patients with AF. The present single center study enrolled 73 participants with AF and 72 healthy age-matched controls. Serum catestatin concentrations were markedly higher in AF patients than controls (14.11 (10.21-26.02) ng/mL vs. 10.93 (5.70-20.01) ng/mL, = 0.013). Furthermore, patients with a more severe form of AF had significantly higher serum catestatin (17.56 (12.80-40.35) vs. 10.98 (8.38-20.91) ng/mL, 0.001). Patients with higher CHADS-VASc scores (17.58 (11.89-37.87) vs. 13.02 (8.47-22.75) ng/mL, = 0.034) and higher NT-proBNP levels (17.58 (IQR 13.91-34.62) vs. 13.23 (IQR 9.04-22.61), = 0.036) had significantly higher serum catestatin concentrations. Finally, AF duration correlated negatively with serum catestatin levels (r = -0.348, = 0.003). The results of the present study implicate the promising role of catestatin in the intricate pathophysiology of AF, which should be explored in future research.
自主神经系统在引发和维持心房颤动（AF）方面至关重要。抑癌素是一种多功能肽，可调节心血管系统，并通过阻断儿茶酚胺的释放来减少交感神经系统有害的过度活动。我们旨在确定这些个体的血清抑癌素浓度是否与AF严重程度、持续时间指标以及各种临床和实验室指标相关，以更好地界定抑癌素在AF患者中的临床价值。本单中心研究纳入了73例AF患者和72例年龄匹配的健康对照。AF患者的血清抑癌素浓度显著高于对照组（14.11（10.21 - 26.02）ng/mL对10.93（5.70 - 20.01）ng/mL，P = 0.013）。此外，AF病情更严重的患者血清抑癌素水平显著更高（17.56（12.80 - 40.35）对10.98（8.38 - 20.91）ng/mL，P < 0.001）。CHADS - VASc评分较高的患者（17.58（11.89 - 37.87）对13.02（8.47 - 22.75）ng/mL，P = 0.034）和NT - proBNP水平较高的患者（17.58（四分位间距13.91 - 34.62）对13.23（四分位间距9.04 - 22.61），P = 0.036）血清抑癌素浓度显著更高。最后，AF持续时间与血清抑癌素水平呈负相关（r = -0.348，P = 0.003）。本研究结果表明抑癌素在AF复杂的病理生理学中具有潜在作用，应在未来研究中进一步探索。
