Department of Ophthalmology, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, 15355, South Korea.
Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea.
Graefes Arch Clin Exp Ophthalmol. 2023 Jul;261(7):1923-1932. doi: 10.1007/s00417-023-05999-1. Epub 2023 Feb 24.
To investigate whether fundus autofluorescence (FAF) obtained using an ultra-wide field (UWF) fundus camera with an artificial opacity pattern can grade the degree of presbyopia and nuclear cataract.
Sixty eyes of 30 patients were enrolled in this prospective diagnostic study. The nuclear cataract (nuclear color/opalescence (NC/NO)) was graded according to the Lens Opacity Classification System III. The monocular near point of accommodation (NPA) was measured in eyes with NC3/NO3 or less. The mean gray value difference between the central 8 artificial opacity lesions and peripheral 8 artificial opacity lesions in the retinal AF was measured. The correlation between the mean gray value difference, NPA, and nuclear cataract grade was analyzed.
The mean nuclear cataract grade of 60 eyes was 3.2 ± 1.6 and mean NPA of 37 eyes was 45.3 ± 16.1 cm. The mean gray value differences increased with increasing nuclear cataract grade (eyes with NC/NO grade 1, 53.3 ± 11.4; 2, 78.3 ± 13.6; 3, 95.2 ± 12.2; 4, 101.6 ± 11.9; 5, 109.0 ± 22.9; and 6, 121.1 ± 12.0; p < 0.001). The mean gray value difference was positively correlated with both the monocular NPA (R = 0.637; β coefficient = 1.009; 95% CI, 0.748 to 1.271; p < 0.001) and nuclear cataract grade (R = 0.661; β coefficient = 12.437; 95% CI, 10.097 to 14.778; p < 0.001).
The FAF camera with an artificial opacity pattern attached can be used to effectively diagnose the degree of presbyopia and nuclear cataract.
探讨使用具有人工不透明图案的超广角（UWF）眼底相机获得的眼底自发荧光（FAF）能否分级远视和核性白内障的程度。
本前瞻性诊断研究纳入了 30 例患者的 60 只眼。核性白内障（核颜色/乳光（NC/NO））根据 Lens Opacity Classification System III 分级。NC3/NO3 或以下的眼中测量单眼近点调节（NPA）。测量视网膜 AF 中中央 8 个人工不透明病变和周围 8 个人工不透明病变之间的平均灰度差值。分析平均灰度差值、NPA 和核性白内障分级之间的相关性。
60 只眼中的平均核性白内障分级为 3.2 ± 1.6，37 只眼中的平均 NPA 为 45.3 ± 16.1 cm。随着核性白内障分级的增加，平均灰度差值也增加（NC/NO 分级 1 的眼为 53.3 ± 11.4；2 级为 78.3 ± 13.6；3 级为 95.2 ± 12.2；4 级为 101.6 ± 11.9；5 级为 109.0 ± 22.9；6 级为 121.1 ± 12.0；p < 0.001）。平均灰度差值与单眼 NPA（R = 0.637；β系数 = 1.009；95%置信区间，0.748 至 1.271；p < 0.001）和核性白内障分级（R = 0.661；β系数 = 12.437；95%置信区间，10.097 至 14.778；p < 0.001）均呈正相关。
带有人工不透明图案的 FAF 相机可有效诊断远视和核性白内障的程度。
