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乳腺癌治疗期间及之后的脱发

Hair loss during and after breast cancer therapy.

作者信息

Rose Lucy, Lustberg Maryam, Ruddy Kathryn J, Cathcart-Rake Elizabeth, Loprinzi Charles, Dulmage Brittany

机构信息

The Ohio State University College of Medicine, Columbus, OH, USA.

Yale Cancer Center, New Haven, CT, USA.

出版信息

Support Care Cancer. 2023 Feb 24;31(3):186. doi: 10.1007/s00520-023-07634-5.

DOI:10.1007/s00520-023-07634-5
PMID:36826602
Abstract

For patients diagnosed with breast cancer, alopecia can be a distressing side effect of treatment. Major surgeries, cytotoxic chemotherapy, and endocrine therapy may result in several different types of alopecia. This article reviews the underlying mechanisms, etiology, prevention strategies, and treatment options for chemotherapy-induced alopecia, telogen effluvium, and endocrine-induced alopecia. Here, we aim to provide breast oncologists with a review of the types of hair loss related to cancer therapy and current preventative and treatment options to facilitate informative patient counseling.

摘要

对于被诊断患有乳腺癌的患者,脱发可能是治疗带来的令人苦恼的副作用。大手术、细胞毒性化疗和内分泌治疗可能导致几种不同类型的脱发。本文综述了化疗引起的脱发、休止期脱发和内分泌引起的脱发的潜在机制、病因、预防策略和治疗选择。在此,我们旨在为乳腺肿瘤学家提供一份与癌症治疗相关的脱发类型以及当前预防和治疗选择的综述,以便为患者提供信息丰富的咨询服务。

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Hair loss during and after breast cancer therapy.乳腺癌治疗期间及之后的脱发
Support Care Cancer. 2023 Feb 24;31(3):186. doi: 10.1007/s00520-023-07634-5.
2
'Atrophic telogen effluvium' from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D analogue in humans.细胞毒性药物所致的“萎缩性休止期脱发”以及一项关于研究局部应用维生素D类似物预处理对人类可能的保护作用的随机对照试验。
Br J Dermatol. 2005 Jul;153(1):103-12. doi: 10.1111/j.1365-2133.2005.06608.x.
3
Sequential cyclic changes of hair roots revealed by dermoscopy demonstrate a progressive mechanism of diffuse alopecia areata over time.皮肤镜检查所揭示的毛根连续周期性变化表明,随着时间推移,斑秃呈进行性发展机制。
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Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl.拔毛癖:一名11岁女孩的怪异脱发模式。
Acta Dermatovenerol Croat. 2016 Jun;24(2):150-3.
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Hair loss: alopecia fears and realities for survivors of breast cancer-a narrative review.脱发:乳腺癌幸存者的脱发恐惧与现实——叙事性综述。
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Anagen effluvium.生长期脱发。
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Female pattern alopecia and telogen effluvium: figuring out diffuse alopecia.女性型脱发和休止期脱发:解读弥漫性脱发
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Nutrients. 2025 Apr 25;17(9):1451. doi: 10.3390/nu17091451.
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Approaches to management of endocrine therapy-induced alopecia in breast cancer patients.乳腺癌患者内分泌治疗所致脱发的管理方法。
Support Care Cancer. 2025 Feb 17;33(3):199. doi: 10.1007/s00520-025-09258-3.
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Chemotherapy-Induced Alopecia in Ovarian Cancer: Incidence, Mechanisms, and Impact Across Treatment Regimens.

本文引用的文献

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Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer.乳腺癌激素治疗所致脱发的临床情况、发病机制及治疗选择
Explor Target Antitumor Ther. 2021;2(5):490-495. doi: 10.37349/etat.2021.00059. Epub 2021 Oct 31.
2
Permanent chemotherapy-induced alopecia after hematopoietic stem cell transplantation treated with low-dose oral minoxidil.造血干细胞移植后永久性化疗所致脱发采用小剂量口服米诺地尔治疗。
JAAD Case Rep. 2022 Feb 17;22:64-67. doi: 10.1016/j.jdcr.2022.01.035. eCollection 2022 Apr.
3
Telogen Effluvium - a review of the science and current obstacles.
卵巢癌化疗所致脱发:发病率、机制及不同治疗方案的影响
Cancers (Basel). 2025 Jan 26;17(3):411. doi: 10.3390/cancers17030411.
4
Madarosis Among Breast Cancer Survivors.乳腺癌幸存者中的眉毛缺失。
Clin Breast Cancer. 2024 Dec;24(8):e757-e763. doi: 10.1016/j.clbc.2024.09.002. Epub 2024 Sep 6.
休止期脱发:科学综述与当前障碍
J Dermatol Sci. 2021 Mar;101(3):156-163. doi: 10.1016/j.jdermsci.2021.01.007. Epub 2021 Jan 23.
4
Does Scalp Cooling Have the Same Efficacy in Black Patients Receiving Chemotherapy for Breast Cancer?头皮冷却在接受乳腺癌化疗的黑种人患者中的疗效是否相同?
Oncologist. 2021 Apr;26(4):292-e548. doi: 10.1002/onco.13690. Epub 2021 Feb 17.
5
Considerations for the Use of Scalp Cooling Devices in Black Patients.黑人患者使用头皮冷却装置的注意事项。
J Clin Oncol. 2020 Oct 20;38(30):3575-3576. doi: 10.1200/JCO.20.02130. Epub 2020 Sep 8.
6
Prevention and Treatment of Chemotherapy-Induced Alopecia.化疗所致脱发的防治
Dermatol Pract Concept. 2020 Jun 29;10(3):e2020074. doi: 10.5826/dpc.1003a74. eCollection 2020 Jul.
7
The impact of cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) on the incidence of alopecia in patients with metastatic breast cancer (BC).细胞周期蛋白依赖性激酶4和6抑制剂(CDK4/6i)对转移性乳腺癌(BC)患者脱发发生率的影响。
Acta Oncol. 2020 Jun;59(6):723-725. doi: 10.1080/0284186X.2020.1738547. Epub 2020 Mar 13.
8
Permanent chemotherapy-induced alopecia: awareness and attitudes among health care providers.永久性化疗导致的脱发:医护人员的认知和态度。
Support Care Cancer. 2020 Jun;28(6):2887-2890. doi: 10.1007/s00520-019-05169-2. Epub 2019 Nov 19.
9
Are all cyclin-dependent kinases 4/6 inhibitors created equal?所有细胞周期蛋白依赖性激酶4/6抑制剂都一样吗?
NPJ Breast Cancer. 2019 Aug 29;5:27. doi: 10.1038/s41523-019-0121-y. eCollection 2019.
10
Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study.乳腺癌患者的永久性化疗性脱发:一项为期 3 年的前瞻性队列研究。
Oncologist. 2019 Mar;24(3):414-420. doi: 10.1634/theoncologist.2018-0184. Epub 2018 Aug 17.