Lin Chuang-Yu, Huang Te-Yang, Fu Wei-Chang, Su Wen-Ta
Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Department of Orthopedic Surgery, Mackay Memorial Hospital, Taipei 104217, Taiwan.
J Funct Biomater. 2023 Feb 9;14(2):95. doi: 10.3390/jfb14020095.
is a medicinal plant used in complementary and alternative medicines. extracts contain many compounds with medical functions, of which the most critical is ginkgolide B (GB). The major role that GB plays is to function as an antagonist to the platelet-activating factor, which is one of the causes of thrombosis and cardiovascular diseases. Currently, GB is obtained mainly through extraction and purification from the leaves of ; however, the yield of GB is low. Alternatively, the immobilized cultivation of ginkgo calluses with biomaterial scaffolds and the addition of organic elicitors to activate the cell defense mechanisms were found to stimulate increases in GB production. The aim of this study was to use calluses for immobilized cultures with different elicitors to find a more suitable method of ginkgolide B production via a recycling process.
是一种用于补充和替代医学的药用植物。提取物含有许多具有医学功能的化合物，其中最关键的是银杏内酯B（GB）。GB的主要作用是作为血小板活化因子的拮抗剂，血小板活化因子是血栓形成和心血管疾病的原因之一。目前，GB主要通过从银杏叶中提取和纯化获得；然而，GB的产量很低。另外，发现用生物材料支架固定培养银杏愈伤组织并添加有机诱导剂以激活细胞防御机制可刺激GB产量增加。本研究的目的是使用愈伤组织进行不同诱导剂的固定培养，以通过循环过程找到更合适的银杏内酯B生产方法。
