美托洛尔过量导致的死亡

Fatality resulting from metoprolol overdose.

作者信息

Rohrig T P, Rundle D A, Leifer W N

机构信息

Kansas Bureau of Investigation, Toxicology Laboratory, Topeka 66612.

出版信息

J Anal Toxicol. 1987 Sep-Oct;11(5):231-2. doi: 10.1093/jat/11.5.231.

DOI:10.1093/jat/11.5.231

PMID:3682785

Abstract

A death due to an intentional overdose of metoprolol is described. The drug was quantified by gas chromatography, and identification was confirmed by gas chromatography/mass spectrometry. Metoprolol concentrations in blood, bile, urine, and vitreous humor were 19.8 mg/L, 83.1 mg/L, 1.6 mg/L, and 15.1 mg/L, respectively. A blood ethanol concentration of 0.25 g/100 mL was the only other significant toxicologic finding.

摘要

本文描述了一例因故意过量服用美托洛尔导致的死亡案例。通过气相色谱法定量该药物，并通过气相色谱/质谱法进行确证。血液、胆汁、尿液和玻璃体液中美托洛尔的浓度分别为19.8 mg/L、83.1 mg/L、1.6 mg/L和15.1 mg/L。唯一其他显著的毒理学发现是血液乙醇浓度为0.25 g/100 mL。