Xun Min, Zhang Jie, Wu Meichun, Chen Yuping
Institute of Pharmacy & Pharmacology, School of Pharmaceutical Science, University of South China, Hengyang 421001, China.
Hengyang Medical School, University of South China, Hengyang 421001, China; School of Nursing, University of South China, Hengyang 421001, China.
Int J Biochem Cell Biol. 2023 Apr;157:106392. doi: 10.1016/j.biocel.2023.106392. Epub 2023 Feb 23.
The active proliferation and migration of vascular smooth muscle cells supports the healing of vessel damage while their abnormal aggression or destitution contribute to the aberrant intima-medial structure and function in various cardiovascular diseases, so the understanding of the proliferation disorders of vascular smooth muscle cell and the related mechanism is the basis of effective intervention and control for cardiovascular diseases. Recently, long non-coding RNAs have stood out as upstream switchers for multiple proliferative signaling pathways and molecules, and many of them have been shown to conduce to the dysregulated proliferation and apoptosis of vascular smooth muscle cells under various pathogenic stimuli. This article discusses the long non-coding RNAs disclosed and linked to atherosclerosis, pulmonary hypertension, and aneurysms, and focuses upon their modulation of vascular smooth muscle cell population affecting three deadly cardiovascular diseases.
血管平滑肌细胞的活跃增殖和迁移有助于血管损伤的愈合，而其异常增殖或缺乏则会导致各种心血管疾病中内膜-中膜结构和功能异常，因此了解血管平滑肌细胞增殖紊乱及其相关机制是有效干预和控制心血管疾病的基础。近年来，长链非编码RNA作为多种增殖信号通路和分子的上游调控因子崭露头角，其中许多已被证明在各种致病刺激下会导致血管平滑肌细胞增殖失调和凋亡。本文讨论了已揭示的与动脉粥样硬化、肺动脉高压和动脉瘤相关的长链非编码RNA，并着重阐述了它们对影响三种致命心血管疾病的血管平滑肌细胞数量的调节作用。
