Department of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.
Faculty of Biology and Medicine, University of Lausanne (UNIL), 1011 Lausanne, Switzerland.
Tomography. 2023 Jan 24;9(1):166-177. doi: 10.3390/tomography9010015.
Lung cancer screening (LCS) programs through low-dose Computed Tomography (LDCT) are being implemented in several countries worldwide. Radiation exposure of healthy individuals due to prolonged CT screening rounds and, eventually, the additional examinations required in case of suspicious findings may represent a concern, thus eventually reducing the participation in an LCS program. Therefore, the present review aims to assess the potential radiation risk from LDCT in this setting, providing estimates of cumulative dose and radiation-related risk in LCS in order to improve awareness for an informed and complete attendance to the program. After summarizing the results of the international trials on LCS to introduce the benefits coming from the implementation of a dedicated program, the screening-related and participant-related factors determining the radiation risk will be introduced and their burden assessed. Finally, future directions for a personalized screening program as well as technical improvements to reduce the delivered dose will be presented.
肺癌筛查（LCS）计划通过低剂量计算机断层扫描（LDCT）在世界上几个国家实施。由于长期 CT 筛查轮次以及最终在可疑发现时需要进行的额外检查，健康个体的辐射暴露可能会引起关注，从而最终降低参与 LCS 计划的意愿。因此，本综述旨在评估这种情况下 LDCT 的潜在辐射风险，提供 LCS 中累积剂量和与辐射相关风险的估计，以提高对计划的知情和全面参与的意识。在总结 LCS 的国际试验结果以介绍实施专门计划带来的益处后，将介绍确定辐射风险的筛查相关和参与者相关因素，并评估其负担。最后，将介绍个性化筛查计划的未来方向以及降低剂量的技术改进。
