大鼠主要组织相容性复合体亚区在同种异体肾移植排斥反应及被动增强中的作用。
The role of subregions of the rat major histocompatibility complex in the rejection and passive enhancement of renal allografts.
作者信息
Gallico G G, Butcher G W, Howard J C
出版信息
J Exp Med. 1979 Jan 1;149(1):244-53. doi: 10.1084/jem.149.1.244.
The laboratory recombinant haplotype H-1acl of the Norway rat has been used in studies of the rejection and passive enhancement of kidney allografts. While the full H-1a haplotype provoked acute rejection, neither of the isolated subregions, H-1Aa and H-1Ba, did so. It was also found that alloantisera raised against either the H-1Aa or the H-1Ba antigens would enhance the grafts. It is suggested that both MHC subregions contain a histocompatibility locus (i) for kidney (as they do for skin) and that in the genetic combinations studied only incompatibility for both provokes a response sufficient for rejection. In other combinations, however, single region incompatibilities may be sufficient.
挪威大鼠的实验室重组单倍型H-1acl已用于肾移植排斥反应和被动增强的研究。完整的H-1a单倍型可引发急性排斥反应，而分离出的亚区域H-1Aa和H-1Ba均不会引发这种反应。还发现，针对H-1Aa或H-1Ba抗原产生的同种抗血清可增强移植效果。有人提出，两个主要组织相容性复合体（MHC）亚区域都含有一个肾脏组织相容性位点（就像它们对皮肤一样），并且在所研究的基因组合中，只有两个区域都不相容才会引发足以导致排斥反应的应答。然而，在其他组合中，单个区域不相容可能就足够了。
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