Stuart F P, Saitoh T, Fitch F W
Science. 1968 Jun 28;160(3835):1463-5. doi: 10.1126/science.160.3835.1463.
Kidneys were transplanted across a major genetic barrier (Ag-B locus), from LewisxBN F(1) hybrid rats into bilaterally nephrectomized Lewis rats. Survival of grafts is prolonged (indefinite?) in rats treated with a combination of (i) intravenous injection of donor spleen cells 1 day before the graft, and (ii) passive immunization with antiserum prepared in rats of the recipient strain against donor spleen and lymph-node cells. The recipient's immune response to other antigens is not impaired.
将肾脏跨越主要遗传屏障（Ag - B位点），从Lewis×BN F(1)杂种大鼠移植到双侧肾切除的Lewis大鼠体内。在用以下组合处理的大鼠中，移植物的存活时间延长（不确定是否无限期？）：（i）在移植前1天静脉注射供体脾细胞，以及（ii）用受体品系大鼠制备的抗供体脾细胞和淋巴结细胞的抗血清进行被动免疫。受体对其他抗原的免疫反应未受损。
