Chakraborty Debjit, Debnath Falguni, Kanungo Suman, Mukhopadhyay Sandip, Chakraborty Nabanita, Basu Rivu, Das Palash, Datta Kalpana, Ganguly Suman, Banerjee Prithwijit, Kshirsagar Nilima, Dutta Shanta
ICMR-National Institute of Cholera and Enteric Disease, Kolkata 700010, India.
R. G Kar Medical College & Hospital, Kolkata 700004, India.
Trop Med Infect Dis. 2023 Jan 28;8(2):88. doi: 10.3390/tropicalmed8020088.
Drug utilisation studies are relevant for the analysis of prescription rationality and are pertinent in today's context of the increasing burden of antimicrobial resistance. Prescriptions for patients with diarrhoea or Acute Respiratory Infection (ARI) have been analysed in this study to understand the prescription pattern among various categories of prescribers in two tertiary care centers.
This cross-sectional study was conducted from August 2019 to December 2020 in the medicine and pediatrics outpatient departments of two government teaching hospitals in West Bengal, India. A total of 630 prescriptions were evaluated against WHO standards. Prescriptions were assessed by a 'Rational Use of Medicine Consensus committee' approach.
The Fixed Dose Combination (FDC) was used in half of the patients (51%). Both the generic prescription (23.3%) and adherence to hospital formulary rates (36.5%) were low. The antibiotics prescription rate was high (57%), and it was higher for diarrhoea than ARI. Deviations from the standard treatment guidelines were found in 98.9% of prescriptions. Deviations were commonly found with prescriptions written by the junior doctors (99.6%).
Irrational prescribing patterns prevail in tertiary care centers and indicate the necessity of awareness generation and capacity building among prescribers regarding AMR and its unseen consequences.
药物利用研究对于分析处方合理性具有重要意义，在当前抗微生物药物耐药性负担日益加重的背景下也具有相关性。本研究分析了腹泻或急性呼吸道感染（ARI）患者的处方，以了解两个三级医疗中心各类开处方者的处方模式。
本横断面研究于2019年8月至2020年12月在印度西孟加拉邦的两家政府教学医院的内科和儿科门诊进行。根据世界卫生组织标准对总共630份处方进行了评估。采用“合理用药共识委员会”方法对处方进行评估。
一半患者（51%）使用了固定剂量复方制剂（FDC）。通用名处方率（23.3%）和遵循医院处方集的比例（36.5%）均较低。抗生素处方率较高（57%），腹泻患者的抗生素处方率高于ARI患者。98.9%的处方存在偏离标准治疗指南的情况。偏离情况在初级医生开具的处方中最为常见（99.6%）。
三级医疗中心存在不合理的处方模式，这表明有必要提高开处方者对抗微生物药物耐药性及其潜在后果的认识并加强其能力建设。
