使用世界卫生组织指标评估非甾体抗炎药使用模式：恰蒂斯加尔邦一家三级护理教学医院的横断面研究
Assessment of nonsteroidal anti-inflammatory drug use pattern using World Health Organization indicators: A cross-sectional study in a tertiary care teaching hospital of Chhattisgarh.
作者信息
R Vaishnavi P R, Gaikwad Nitin, Dhaneria S P
机构信息
Intern, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Department of Pharmacology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
出版信息
Indian J Pharmacol. 2017 Nov-Dec;49(6):445-450. doi: 10.4103/ijp.IJP_189_17.
OBJECTIVE
The objective of this study is to assess drug utilization pattern of nonsteroidal anti-inflammatory drugs (NSAIDs) in a tertiary care teaching hospital, Raipur, Chhattisgarh.
MATERIALS AND METHODS
A prospective, cross-sectional observational study was conducted in the outpatient department during 2-month period. After informed consent, the patients visiting pharmacy shop with a prescription were enrolled in the study. Their demographic details and prescription data were recorded in a case record form. The data were analyzed to determine the drug utilization pattern of NSAIDs, using the World Health Organization (WHO) prescribing indicators.
RESULTS
A total of 600 prescriptions were analyzed. Of them, NSAIDs were prescribed in 30.83% encounters. In general, nonselective COX inhibitors were most commonly prescribed. The most commonly prescribed form of NSAID was paracetamol (39.45%). The percentage of NSAIDs prescribed with generic names were almost identical (91.15%), whereas the percentage of NSAIDs prescribed from the National List of Essential Medicine (India) - 2015 (49.72%) was not identical with the WHO standard (100%) which serves as an ideal. In 13.51% encounters, a fixed-dose combination (FDC) of NSAIDs was prescribed. Co-administration of gastroprotective agent with NSAIDs was observed in 24.32% encounters.
CONCLUSION
The prescribing practices of NSAIDs indicate some deviation from the WHO standard. In addition, FDCs of NSAIDs with gastroprotective agents as well as other NSAIDs was also prescribed, which are irrational. This baseline data will be useful to plan further targeted research and to improve prescribing practices at the center. Various strategies such as face-to-face periodic training programs of prescribers, establishing drug and therapeutic committee; drug information centers; and drug bulletins can serve beneficial in improving prescribing practices.
目的
本研究旨在评估印度恰蒂斯加尔邦赖布尔市一家三级护理教学医院非甾体抗炎药（NSAIDs）的用药模式。
材料与方法
在门诊进行了为期2个月的前瞻性横断面观察研究。在获得知情同意后，将持处方前往药房的患者纳入研究。他们的人口统计学细节和处方数据记录在病例记录表中。使用世界卫生组织（WHO）的处方指标对数据进行分析，以确定NSAIDs的用药模式。
结果
共分析了600份处方。其中，30.83%的就诊病例开具了NSAIDs。一般来说，非选择性COX抑制剂是最常用的处方药。NSAID最常用的剂型是对乙酰氨基酚（39.45%）。使用通用名开具的NSAIDs百分比几乎相同（91.15%），而根据《2015年印度基本药物目录》开具的NSAIDs百分比（49.72%）与作为理想标准的WHO标准（100%）不同。在13.51%的就诊病例中，开具了NSAIDs的固定剂量复方制剂（FDC）。在24.32%的就诊病例中观察到NSAIDs与胃保护剂联合使用。
结论
NSAIDs的处方实践表明与WHO标准存在一些偏差。此外，还开具了NSAIDs与胃保护剂以及其他NSAIDs的FDC，这是不合理的。这些基线数据将有助于规划进一步的针对性研究，并改善该中心的处方实践。各种策略，如对开处方者进行面对面的定期培训项目、设立药物与治疗委员会、药物信息中心以及发布药物公告，可能有助于改善处方实践。
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