Universitat Autonoma de Barcelona, Bellaterra, Spain.
Department of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d'Hebron, 119 Passeig de la Vall d'Hebron, 08035, Barcelona, Spain.
BMC Gastroenterol. 2023 Feb 24;23(1):51. doi: 10.1186/s12876-023-02684-9.
The relevance of elevated serum triglyceride (TG) levels in the early stages of acute pancreatitis (AP) not induced by hypertriglyceridemia (HTG) remains unclear. Our study aims to determine the role of elevated serum TG levels at admission in developing pancreatic necrosis.
We analyzed the clinical data collected prospectively from patients with AP. According to TG levels measured in the first 24 h after admission, we stratified patients into four groups: Normal TG (< 150 mg/dL), Borderline-high TG (150-199 mg/dL), High TG (200-499 mg/dL) and Very high TG (≥ 500 mg/dL). We analyzed the association of TG levels and other risk factors with the development of pancreatic necrosis.
A total of 211 patients were included. In the Normal TG group: 122, in Borderline-high TG group: 38, in High TG group: 44, and in Very high TG group: 7. Pancreatic necrosis developed in 29.5% of the patients in the Normal TG group, 26.3% in the Borderline-high TG group, 52.3% in the High TG group, and 85.7% in the Very high TG group. The trend analysis observed a significant association between higher TG levels and pancreatic necrosis (p = 0.001). A multivariable analysis using logistic regression showed that elevated TG levels ≥ 200 mg/dL (High TG and Very high TG groups) were independently associated with pancreatic necrosis (OR: 3.27, 95% CI - 6.27, p < 0.001).
An elevated TG level at admission ≥ 200 mg/dl is independently associated with the development of pancreatic necrosis. The incidence of pancreatic necrosis increases proportionally with the severity of HTG.
在非高甘油三酯血症（HTG）引起的急性胰腺炎（AP）的早期阶段，血清甘油三酯（TG）水平升高的相关性尚不清楚。我们的研究旨在确定入院时血清 TG 水平升高在胰腺坏死发展中的作用。
我们分析了前瞻性收集的 AP 患者的临床数据。根据入院后 24 小时内测量的 TG 水平，我们将患者分为四组：正常 TG（<150mg/dL）、边缘高 TG（150-199mg/dL）、高 TG（200-499mg/dL）和非常高 TG（≥500mg/dL）。我们分析了 TG 水平和其他危险因素与胰腺坏死发展的关系。
共纳入 211 例患者。正常 TG 组：122 例，边缘高 TG 组：38 例，高 TG 组：44 例，非常高 TG 组：7 例。正常 TG 组患者中胰腺坏死发生率为 29.5%，边缘高 TG 组为 26.3%，高 TG 组为 52.3%，非常高 TG 组为 85.7%。趋势分析观察到较高的 TG 水平与胰腺坏死之间存在显著相关性（p=0.001）。使用逻辑回归的多变量分析表明，TG 水平升高≥200mg/dL（高 TG 和非常高 TG 组）与胰腺坏死独立相关（OR：3.27，95%CI-6.27，p<0.001）。
入院时升高的 TG 水平≥200mg/dl 与胰腺坏死的发展独立相关。HTG 严重程度与胰腺坏死发生率成正比。
