Terrell C L, Hermans P E
Division of Infectious Diseases and Internal Medicine, Mayo Clinic.
Mayo Clin Proc. 1987 Dec;62(12):1116-28. doi: 10.1016/s0025-6196(12)62506-3.
The main antifungal agents used for deep-seated mycotic infections are the broad-spectrum antifungal drug amphotericin B, the narrow-spectrum agent flucytosine, and the newer broad-spectrum agents ketoconazole, miconazole, and itraconazole. Amphotericin B remains the cornerstone of antifungal therapy. For the treatment of cryptococcal meningitis, the current recommendation is for the combined use of amphotericin B and flucytosine. Published clinical experience with the newer agents is limited. Not all patients from whom fungal agents have been isolated require treatment; the extent of the fungal infection should be determined, when possible, for evaluation of the need for treatment.
用于深部真菌感染的主要抗真菌药物有广谱抗真菌药两性霉素B、窄谱药物氟胞嘧啶以及较新的广谱药物酮康唑、咪康唑和伊曲康唑。两性霉素B仍然是抗真菌治疗的基石。对于隐球菌性脑膜炎的治疗，目前的建议是联合使用两性霉素B和氟胞嘧啶。关于这些较新药物的已发表临床经验有限。并非所有分离出真菌病原体的患者都需要治疗；应尽可能确定真菌感染的程度，以评估是否需要治疗。
