Hardan Louis, Chedid Jean Claude Abou, Bourgi Rim, Cuevas-Suárez Carlos Enrique, Lukomska-Szymanska Monika, Tosco Vincenzo, Monjarás-Ávila Ana Josefina, Jabra Massa, Salloum-Yared Fouad, Kharouf Naji, Mancino Davide, Haikel Youssef
Department of Restorative Dentistry, School of Dentistry, Saint Joseph University, Beirut 1107 2180, Lebanon.
Department of Pediatric Dentistry, Faculty of Dentistry, Saint Joseph University, Beirut 1107 2180, Lebanon.
Bioengineering (Basel). 2023 Feb 6;10(2):214. doi: 10.3390/bioengineering10020214.
Currently, it remains unclear which specific peptides could be appropriate for applications in different fields of dentistry. The aim of this scoping review was to scan the contemporary scientific papers related to the types, uses and applications of peptides in dentistry at the moment. Literature database searches were performed in the following databases: PubMed/MEDLINE, Scopus, Web of Science, Embase, and Scielo. A total of 133 articles involving the use of peptides in dentistry-related applications were included. The studies involved experimental designs in animals, microorganisms, or cells; clinical trials were also identified within this review. Most of the applications of peptides included caries management, implant osseointegration, guided tissue regeneration, vital pulp therapy, antimicrobial activity, enamel remineralization, periodontal therapy, the surface modification of tooth implants, and the modification of other restorative materials such as dental adhesives and denture base resins. The in vitro and in vivo studies included in this review suggested that peptides may have beneficial effects for treating early carious lesions, promoting cell adhesion, enhancing the adhesion strength of dental implants, and in tissue engineering as healthy promotors of the periodontium and antimicrobial agents. The lack of clinical trials should be highlighted, leaving a wide space available for the investigation of peptides in dentistry.
目前，尚不清楚哪些特定的肽适用于牙科的不同领域。本范围综述的目的是梳理当下与牙科中肽的类型、用途和应用相关的科学文献。在以下数据库中进行了文献数据库检索：PubMed/MEDLINE、Scopus、科学网、Embase和Scielo。共纳入133篇涉及肽在牙科相关应用的文章。这些研究包括在动物、微生物或细胞上的实验设计；本综述中也确定了临床试验。肽的大多数应用包括龋齿管理、种植体骨整合、引导组织再生、牙髓活力治疗、抗菌活性、牙釉质再矿化、牙周治疗、牙种植体的表面改性以及其他修复材料（如牙科粘合剂和义齿基托树脂）的改性。本综述中纳入的体外和体内研究表明，肽可能对治疗早期龋损、促进细胞粘附、增强牙种植体的粘附强度以及在组织工程中作为牙周健康促进剂和抗菌剂具有有益作用。应强调临床试验的缺乏，这为牙科中肽的研究留出了广阔空间。
