Dos Santos Jousielle Márcia, Taiar Redha, Ribeiro Vanessa Gonçalves César, da Silva Lage Vanessa Kelly, Scheidt Figueiredo Pedro Henrique, Costa Henrique Silveira, Pereira Lima Vanessa, Sañudo Borja, Bernardo-Filho Mário, Sá-Caputo Danúbia da Cunha de, Dias Peixoto Marco Fabrício, Mendonça Vanessa Amaral, Rapin Amandine, Lacerda Ana Cristina Rodrigues
Multicenter Graduate Program in Physiological Sciences, Brazilian Society of Physiology, Diamantina 39100-000, Brazil.
Graduate Program in Functional Performance and Rehabilitation, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina 39100-000, Brazil.
Bioengineering (Basel). 2023 Feb 16;10(2):260. doi: 10.3390/bioengineering10020260.
(1) Background: Mitochondrial dysfunction and redox imbalance seem to be involved in fibromyalgia (FM) pathogenesis. The results of our previous studies suggest that whole-body vibration training (WBVT) would improve redox status markers, increase blood irisin levels, and ameliorate the body composition of women with FM. (2) Objective: The current study aimed to investigate WBVT on oxidative stress markers, plasma irisin levels, and body composition in women with FM. (3) Methods: Forty women with FM were randomized into WBVT or untrained (UN) groups. Before and after 6 weeks of WBVT, body composition was assessed by dual-energy radiological absorptiometry (DXA), and inflammatory marker activities were measured by enzymatic assay. (4) Results: Body composition, blood irisin levels, and oxidative stress markers were similar between UN and WBVT groups before the intervention. After 6 weeks of intervention, the WBVT group presented higher irisin levels (WBVT: 316.98 ± 109.24 mg·dL³, WBVT: 477.61 ± 267.92 mg·dL³, = 0.01) and lower TBARS levels (UN: 0.39 ± 0.02 nmol MDA/mg protein, WBVT: 0.24 ± 0.06 nmol MDA/mg protein, = 0.001) and visceral adipose tissue mass (UN: 1.37 ± 0.49 kg, WBVT: 0.69 ± 0.54 kg, = 0.001) compared to the UN group. (5) Conclusions: Six weeks of WBVT improves blood redox status markers, increases irisin levels, and reduces visceral adipose tissue mass, favoring less cell damage and more outstanding oxidative balance in women with FM.
(1) 背景：线粒体功能障碍和氧化还原失衡似乎与纤维肌痛（FM）的发病机制有关。我们之前的研究结果表明，全身振动训练（WBVT）可改善氧化还原状态标志物，提高血液鸢尾素水平，并改善FM女性的身体成分。(2) 目的：本研究旨在调查WBVT对FM女性氧化应激标志物、血浆鸢尾素水平和身体成分的影响。(3) 方法：40名FM女性被随机分为WBVT组或未训练（UN）组。在WBVT 6周前后，通过双能X线吸收法（DXA）评估身体成分，并通过酶法测定炎症标志物活性。(4) 结果：干预前，UN组和WBVT组的身体成分、血液鸢尾素水平和氧化应激标志物相似。干预6周后，与UN组相比，WBVT组的鸢尾素水平更高（WBVT组：316.98±109.24 mg·dL³，WBVT组：477.61±267.92 mg·dL³，P = 0.01），硫代巴比妥酸反应物（TBARS）水平更低（UN组：0.39±0.02 nmol丙二醛/mg蛋白质，WBVT组：0.24±0.06 nmol丙二醛/mg蛋白质，P = 0.001），内脏脂肪组织质量更低（UN组：1.37±0.49 kg，WBVT组：0.69±0.54 kg，P = 0.001）。(5) 结论：6周的WBVT可改善血液氧化还原状态标志物，提高鸢尾素水平，并减少内脏脂肪组织质量，有利于减少FM女性的细胞损伤，实现更显著的氧化平衡。
