Santos J M, Mendonça V A, Ribeiro V G C, Tossige-Gomes R, Fonseca S F, Prates A C N, Flor J, Oliveira A C C, Martins J B, Garcia B C C, Leite H R, Figueiredo P H S, Bernardo-Filho M, Lacerda A C R
Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
Braz J Med Biol Res. 2019;52(8):e8688. doi: 10.1590/1414-431X20198688. Epub 2019 Aug 5.
The objective of this study was to investigate the effect of whole body vibration (WBV) exercise on oxidative stress markers in a group of women with fibromyalgia (FM) compared to a group of healthy women (CT). Twenty-one women diagnosed with FM and 21 age- and weight-matched healthy women were enrolled the study. Plasma oxidative stress markers (primary outcomes) were evaluated at rest and after WBV, and included thiobarbituric acid reactive substances (TBARS), iron reduction capacity (FRAP), superoxide dismutase antioxidant enzymes activity (SOD), and catalase (CAT). At rest, the FM group had higher TBARS (P<0.001) and FRAP (P<0.001), and lower CAT (P=0.005) compared to the CT. In the CT group, the WBV had no effect on TBARS (P=0.559) and FRAP (P=0.926), whereas it increased both SOD (P<0.001) and CAT (P<0.001). In the FM group, the WBV reduced TBARS (p <0.001), FRAP (P<0.001), and CAT (P=0.005), while it increased SOD (P=0.019). There was an interaction effect (moments vs groups) in the TBARS (effect size=1.34), FRAP (effect size=0.93), CAT (effect size=1.45), and SOD (effect size=1.44) (P<0.001). A single trial of WBV exercise improved all oxidant and antioxidant parameters towards a greater adaptation to the stress response in FM women.
本研究的目的是调查全身振动（WBV）运动对一组纤维肌痛（FM）女性与一组健康女性（CT）氧化应激标志物的影响。21名被诊断为FM的女性和21名年龄及体重匹配的健康女性参与了该研究。在静息状态和WBV运动后评估血浆氧化应激标志物（主要指标），包括硫代巴比妥酸反应性物质（TBARS）、铁还原能力（FRAP）、超氧化物歧化酶抗氧化酶活性（SOD）和过氧化氢酶（CAT）。静息时，与CT组相比，FM组的TBARS（P<0.001）和FRAP（P<0.001）更高，而CAT更低（P=0.005）。在CT组中，WBV对TBARS（P=0.559）和FRAP（P=0.926）没有影响，而它增加了SOD（P<0.001）和CAT（P<0.001）。在FM组中，WBV降低了TBARS（P<0.001）、FRAP（P<0.001）和CAT（P=0.005），而增加了SOD（P=0.019）。在TBARS（效应大小=1.34）、FRAP（效应大小=0.93）、CAT（效应大小=1.45）和SOD（效应大小=1.44）方面存在交互作用（时间与组）（P<0.001）。单次WBV运动试验改善了所有氧化和抗氧化参数，使FM女性对压力反应有更好的适应性。
