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铈掺杂自组装纳米颗粒作为一种新型抗氧化剂递送系统，可在暴露于缺血样条件的皮质神经元中维持线粒体功能。

Cerium-Doped Self-Assembling Nanoparticles as a Novel Anti-Oxidant Delivery System Preserving Mitochondrial Function in Cortical Neurons Exposed to Ischemia-like Conditions.

作者信息

Nele Valeria, Tedeschi Valentina, Campani Virginia, Ciancio Raffaella, Angelillo Alessia, Graziano Sossio Fabio, De Rosa Giuseppe, Secondo Agnese

机构信息

Department of Pharmacy, University of Naples Federico II, Via D. Montesano, 80131 Naples, Italy.

Division of Pharmacology, Department of Neuroscience, Reproductive and Odontostomatological Sciences, School of Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

出版信息

Antioxidants (Basel). 2023 Feb 2;12(2):358. doi: 10.3390/antiox12020358.

DOI:10.3390/antiox12020358
PMID:36829918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9952397/
Abstract

Neurodegenerative diseases are characterized by mitochondrial dysfunction leading to abnormal levels of reactive oxygen species (ROS), making the use of ROS-scavenging nanomaterials a promising therapeutic approach. Here, we combined the unique ROS-scavenging properties of cerium-based nanomaterials with the lipid self-assembling nanoparticles (SANP) technology. We optimized the preparation of cerium-doped SANP (Ce-SANP) and characterized the formulations in terms of both physiochemical and biological properties. Ce-SANP exhibited good colloidal properties and were able to mimic the activity of two ROS-scavenging enzymes, namely peroxidase and super oxide dismutase. Under ischemia-like conditions, Ce-SANP could rescue neuronal cells from mitochondrial suffering by reducing ROS production and preventing ATP level reduction. Furthermore, Ce-SANP prevented mitochondrial Ca homeostasis dysfunction, partially restoring mitochondrial Ca handling. Taken together, these results highlight the potential of the anti-oxidant Ce-SANP platform technology to manage ROS levels and mitochondrial function for the treatment of neurodegenerative diseases.

摘要

神经退行性疾病的特征是线粒体功能障碍，导致活性氧（ROS）水平异常，这使得使用ROS清除纳米材料成为一种有前景的治疗方法。在此，我们将铈基纳米材料独特的ROS清除特性与脂质自组装纳米颗粒（SANP）技术相结合。我们优化了铈掺杂SANP（Ce-SANP）的制备，并从物理化学和生物学特性方面对制剂进行了表征。Ce-SANP表现出良好的胶体性质，并且能够模拟两种ROS清除酶即过氧化物酶和超氧化物歧化酶的活性。在缺血样条件下，Ce-SANP可以通过减少ROS产生和防止ATP水平降低来挽救神经元细胞免受线粒体损伤。此外，Ce-SANP可防止线粒体钙稳态功能障碍，部分恢复线粒体钙处理能力。综上所述，这些结果突出了抗氧化Ce-SANP平台技术在控制ROS水平和线粒体功能以治疗神经退行性疾病方面的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d02/9952397/d1eb84c8215f/antioxidants-12-00358-g008.jpg
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