Jiménez-Jiménez Félix Javier, Alonso-Navarro Hortensia, García-Martín Elena, Agúndez José A G
Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Ronda del Sur 10, E-28500 Arganda del Rey, Spain.
University Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, E-10071 Cáceres, Spain.
Antioxidants (Basel). 2023 Feb 20;12(2):533. doi: 10.3390/antiox12020533.
It is well known that coenzyme Q (CoQ) has important antioxidant properties. Because one of the main mechanisms involved in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative diseases is oxidative stress, analysis of the concentrations of CoQ in different tissues of AD patients and with other dementia syndromes and the possible therapeutic role of CoQ in AD have been addressed in several studies. We performed a systematic review and a meta-analysis of these studies measuring tissue CoQ levels in patients with dementia and controls which showed that, compared with controls, AD patients had similar serum/plasma CoQ levels. We also revised the possible therapeutic effects of CoQ in experimental models of AD and other dementias (which showed important neuroprotective effects of coenzyme Q) and in humans with AD, other dementias, and mild cognitive impairment (with inconclusive results). The potential role of CoQ treatment in AD and in improving memory in aged rodents shown in experimental models deserves future studies in patients with AD, other causes of dementia, and mild cognitive impairment.
众所周知，辅酶Q（CoQ）具有重要的抗氧化特性。由于阿尔茨海默病（AD）和其他神经退行性疾病发病机制中涉及的主要机制之一是氧化应激，因此多项研究探讨了AD患者以及患有其他痴呆综合征患者不同组织中CoQ的浓度分析，以及CoQ在AD中可能的治疗作用。我们对这些测量痴呆患者和对照组织CoQ水平的研究进行了系统评价和荟萃分析，结果表明，与对照相比，AD患者的血清/血浆CoQ水平相似。我们还回顾了CoQ在AD和其他痴呆实验模型（显示辅酶Q具有重要的神经保护作用）以及AD、其他痴呆和轻度认知障碍患者（结果尚无定论）中的可能治疗效果。实验模型显示CoQ治疗在AD中的潜在作用以及改善老年啮齿动物记忆的作用值得在AD患者、其他痴呆病因患者和轻度认知障碍患者中进行进一步研究。
