Khan Omaid Hayat, Zakaria Andee Dzulkarnaen, Hashim Mohd Nizam, Khan Amer Hayat, AlQarni Abdullmoin, AlGethamy Manal, Mahboob Mohammed, Aljoaid Anas Mohammed, Ahmed Nehad Jaser, Haseeb Abdul
Department of Pharmacy, The University of Lahore, Lahore 54590, Pakistan.
Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia.
Antibiotics (Basel). 2023 Jan 19;12(2):208. doi: 10.3390/antibiotics12020208.
Surgical site infections (SSIs) are the most common healthcare-associated infections that occur among surgical patients. Surgical site infections result in longer hospital stays, hospital readmissions, and higher death and morbidity rates. The current study was designed to highlight the importance of such surveillance studies in a Malaysian surgical population with a motive to evaluate and revise concurrent infection control and prevention policies by exploring the burden of surgical site infection and identifying its associated risk factors for future considerations. In this prospective observational cohort study, a total of 216 patients admitted to a surgical ward were identified and studied. Of these 216 patients, 142 elective procedures and 74 emergency procedures were included in the study, of which 13 patients (9.2%) undergoing elective procedures and 15 (20.3%) patients undergoing emergency procedures were SSI positive (OR: 2.5, = 0.02). Among surgical site infections, 21 were superficial and 7 were deep incisional SSI. No case of organ/space SSI was identified. The time taken for SSIs to develop ranged from 2-17 days with a median of 6 days. Risk factors such as presence of comorbidities ( = 0.011), major co-existing medical diagnosis ≥2 ( = 0.02), and pre-existing infection ( = 0.027) were statistically significant. SSI-positive patients experienced an increase in the post-operative length of hospital stay. In the current population, it was seen that identifying patients who were at high risk of malnutrition via MUST and the NNIS risk index will help clinicians in identifying high risk patients and in managing their patients appropriately. Identifying patients who were at high risk of malnutrition will also improve postoperative outcomes considerably.
手术部位感染(SSIs)是外科手术患者中最常见的医疗相关感染。手术部位感染会导致住院时间延长、再次入院以及更高的死亡率和发病率。本研究旨在强调此类监测研究在马来西亚外科手术人群中的重要性,其目的是通过探究手术部位感染的负担并识别其相关危险因素以供未来参考,从而评估和修订现行的感染控制与预防政策。在这项前瞻性观察队列研究中,共确定并研究了216名入住外科病房的患者。在这216名患者中,142例为择期手术,74例为急诊手术,其中13例(9.2%)接受择期手术的患者和15例(20.3%)接受急诊手术的患者手术部位感染呈阳性(比值比:2.5,P = 0.02)。在手术部位感染中,21例为浅表感染,7例为深部切口感染。未发现器官/腔隙感染病例。手术部位感染发生的时间为2至17天,中位数为6天。合并症的存在(P = 0.011)、主要并存疾病≥2种(P = 0.02)以及既往感染(P = 0.027)等危险因素具有统计学意义。手术部位感染呈阳性的患者术后住院时间增加。在当前人群中,通过营养不良通用筛查工具(MUST)和国家医院感染监测系统(NNIS)风险指数识别出有营养不良高风险的患者,将有助于临床医生识别高风险患者并对其进行适当管理。识别出有营养不良高风险的患者也将显著改善术后结局。