Catalano Alessia, Mariconda Annaluisa, Sinicropi Maria Stefania, Ceramella Jessica, Iacopetta Domenico, Saturnino Carmela, Longo Pasquale
Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70126 Bari, Italy.
Department of Science, University of Basilicata, 85100 Potenza, Italy.
Antibiotics (Basel). 2023 Feb 9;12(2):365. doi: 10.3390/antibiotics12020365.
Ruthenium -heterocyclic carbene (NHC) complexes have unique physico-chemical properties as catalysts and a huge potential in medicinal chemistry and pharmacology, exhibiting a variety of notable biological activities. In this review, the most recent studies on ruthenium NHC complexes are summarized, focusing specifically on antimicrobial and antiproliferative activities. Ruthenium NHC complexes are generally active against Gram-positive bacteria, such as , , and are seldom active against Gram-negative bacteria, including , and and fungal strains of The antiproliferative activity was tested against cancer cell lines of human colon, breast, cervix, epidermis, liver and rat glioblastoma cell lines. Ruthenium NHC complexes generally demonstrated cytotoxicity higher than standard anticancer drugs. Further studies are needed to explore the mechanism of action of these interesting compounds.
钌-杂环卡宾（NHC）配合物作为催化剂具有独特的物理化学性质，在药物化学和药理学方面具有巨大潜力，展现出多种显著的生物活性。在本综述中，总结了钌NHC配合物的最新研究，特别关注其抗菌和抗增殖活性。钌NHC配合物通常对革兰氏阳性菌如[具体菌种1]、[具体菌种2]、[具体菌种3]有活性，而对革兰氏阴性菌如[具体菌种4]、[具体菌种5]、[具体菌种6]以及[真菌菌株名称]的真菌菌株很少有活性。针对人结肠、乳腺、宫颈、表皮、肝脏癌细胞系和大鼠胶质母细胞瘤细胞系测试了其抗增殖活性。钌NHC配合物通常表现出比标准抗癌药物更高的细胞毒性。需要进一步研究来探索这些有趣化合物的作用机制。
