Dobiáš Radim, Stevens David A, Havlíček Vladimír
Department of Bacteriology and Mycology, Public Health Institute in Ostrava, Partyzánské Náměstí 2633/7, 702 00 Ostrava, Czech Republic.
Institute of Laboratory Medicine, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic.
Antibiotics (Basel). 2023 Feb 13;12(2):385. doi: 10.3390/antibiotics12020385.
has been designated by the World Health Organization as a critical priority fungal pathogen. Some commercially available diagnostics for many forms of aspergillosis rely on fungal metabolites. These encompass intracellular molecules, cell wall components, and extracellular secretomes. This review summarizes the shortcomings of antibody tests compared to tests of fungal products in body fluids and highlights the application of β-d-glucan, galactomannan, and pentraxin 3 in bronchoalveolar lavage fluids. We also discuss the detection of nucleic acids and next-generation sequencing, along with newer studies on metallophores.
已被世界卫生组织指定为关键优先真菌病原体。许多形式的曲霉病的一些商业可用诊断方法依赖于真菌代谢产物。这些包括细胞内分子、细胞壁成分和细胞外分泌组。本综述总结了抗体检测与体液中真菌产物检测相比的缺点，并强调了β-d-葡聚糖、半乳甘露聚糖和五聚体3在支气管肺泡灌洗液中的应用。我们还讨论了核酸检测和下一代测序，以及关于金属载体的最新研究。
