Suárez-Suárez Nydia Emilce, Lee-Rangel Héctor Aaron, Lizarazo-Chaparro Augusto César, Mendoza-Martínez German David, Espinosa-Reyes Guillermo, Hernández-García Pedro Abel, García-López Juan Carlos, Martínez-García José Antonio, Álvarez-Fuentes Gregorio, Roque-Jiménez José Alejandro
Facultad de Agronomía y Veterinaria, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78321, Mexico.
Centro de Enseñanza Práctica e Investigación en Producción y Salud Animal, Universidad Nacional Autónoma de México, Mexico City 14500, Mexico.
Animals (Basel). 2023 Feb 13;13(4):645. doi: 10.3390/ani13040645.
Previous research indicates that adequate choline nutrition during late gestation improves fetal development. However, there is a lack of studies describing choline's role during early gestation. Thus, the current study hypothesizes that an herbal mixture as a source of choline (Biocholine) positively affects offspring development from ewes supplemented during early gestation. Therefore, the objectives were to evaluate the impact of biocholine on the programming of the offspring early in life through the evaluation of dams and newborn performance. Twenty-eight four-year-old Rambouillet ewes were assigned randomly to two treatments: non-supplementation and 4 gd of biocholine during the early gestation. Compared with the dams without supplementation, the ewes supplemented using biocholine showed no increase in parameters such as birth and weaning weight ( > 0.05). Additionally, the milk yield and quality of colostrum and milk did not present statistical differences ( > 0.05). However, the placental membrane development was reduced in the ewes that received supplementation with biocholine; interestingly, those dams increased the weight of the newborns during the lambing period ( < 0.05). Finally, the current study proposes necessary elucidation of how placental size is programmed and if less placental development has potential benefits in the fetus's development.
先前的研究表明，妊娠后期充足的胆碱营养可改善胎儿发育。然而，缺乏关于胆碱在妊娠早期作用的研究。因此，本研究假设一种作为胆碱来源的草药混合物（生物胆碱）对妊娠早期补充的母羊所产后代的发育有积极影响。所以，研究目的是通过评估母羊和新生羔羊的表现来评估生物胆碱对后代早期生命编程的影响。将28只4岁的兰布耶母羊随机分为两种处理：不补充和在妊娠早期补充4克生物胆碱。与未补充的母羊相比，补充生物胆碱的母羊在出生体重和断奶体重等参数上没有增加（P>0.05）。此外，初乳和乳汁的产量及质量没有统计学差异（P>0.05）。然而，补充生物胆碱的母羊胎盘膜发育减少；有趣的是，这些母羊在产羔期增加了新生羔羊的体重（P<0.05）。最后，本研究提出有必要阐明胎盘大小是如何编程的，以及胎盘发育较少是否对胎儿发育有潜在益处。
