Mendoza-Martínez Germán David, Orzuna-Orzuna José Felipe, Roque-Jiménez José Alejandro, Gloria-Trujillo Adrián, Martínez-García José Antonio, Sánchez-López Nallely, Hernández-García Pedro Abel, Lee-Rangel Héctor Aaron
Departamento de Producción Agrícola y Animal, Universidad Autónoma Metropolitana-Xochimilco, Mexico City 04960, Mexico.
Departamento de Zootecnia, Universidad Autónoma Chapingo, Chapingo 56230, Mexico.
Animals (Basel). 2024 Feb 20;14(5):667. doi: 10.3390/ani14050667.
BioCholine Powder is a polyherbal feed additive composed of , , , and . The objective of this study was to analyze published results that support the hypothesis that the polyherbal product BioCholine Powder has rumen bypass choline metabolites through a meta-analysis and effect size analysis (ES). Using Scopus, Web of Science, ScienceDirect, PubMed, and university dissertation databases, a systematic search was conducted for experiments published in scientific documents that evaluated the effects of BioCholine supplementation on the variables of interest. The analyzed data were extracted from twenty-one publications (fifteen scientific articles, three abstracts, and three graduate dissertations available in institutional libraries). The studies included lamb growing-finishing, lactating ewes and goats, calves, and dairy cows. The effects of BioCholine were analyzed using random effects statistical models to compare the weighted mean difference (WMD) between BioCholine-supplemented ruminants and controls (no BioCholine). Heterogeneity was explored, and three subgroup analyses were performed for doses [(4 (or 5 g/d), 8 (10 g/d)], supplementation in gestating and lactating ewes (pre- and postpartum supplementation), and blood metabolites by species and physiological state (lactating goats, calves, lambs, ewes). Supplementation with BioCholine in sheep increased the average daily lamb gain ( < 0.05), final body weight ( < 0.01), and daily milk yield ( < 0.05) without effects on intake or feed conversion. Milk yield was improved in small ruminants with BioCholine prepartum supplementation ( < 0.10). BioCholine supplementation decreased blood urea ( < 0.01) and increased levels of the liver enzymes alanine transaminase (ALT; < 0.10) and albumin ( < 0.001). BioCholine doses over 8 g/d increased blood glucose, albumin ( < 0.10), cholesterol, total protein, and globulin ( < 0.05). The ES values of BioCholine in retained energy over the control in growing lambs were +7.15% NEm ( < 0.10) and +9.25% NEg ( < 0.10). In conclusion, adding BioCholine Powder to domestic ruminants' diets improves productive performance, blood metabolite indicators of protein metabolism, and liver health, showing its nutraceutical properties where phosphatidylcholine prevails as an alternative that can meet the choline requirements in ruminants.
生物胆碱粉是一种由[具体成分未给出]、[具体成分未给出]、[具体成分未给出]和[具体成分未给出]组成的多草药饲料添加剂。本研究的目的是通过荟萃分析和效应量分析（ES）来分析已发表的结果，以支持多草药产品生物胆碱粉具有瘤胃旁路胆碱代谢物这一假设。利用Scopus、Web of Science、ScienceDirect、PubMed和大学论文数据库，对科学文献中发表的评估补充生物胆碱对感兴趣变量影响的实验进行了系统检索。分析的数据来自21篇出版物（15篇科学文章、3篇摘要和3篇可在机构图书馆获取的研究生论文）。这些研究包括羔羊育肥、泌乳母羊和母山羊、犊牛和奶牛。使用随机效应统计模型分析生物胆碱的效果，以比较补充生物胆碱的反刍动物与对照组（未补充生物胆碱）之间的加权平均差（WMD）。探讨了异质性，并对剂量[（4（或5克/天）、8（10克/天）]、妊娠和泌乳母羊的补充（产前和产后补充）以及按物种和生理状态（泌乳山羊、犊牛、羔羊、母羊）划分的血液代谢物进行了三项亚组分析。在绵羊中补充生物胆碱可提高羔羊平均日增重（P<0.05）、最终体重（P<0.01）和日产奶量（P<0.05），而对采食量或饲料转化率无影响。产前补充生物胆碱可提高小型反刍动物的产奶量（P<0.10）。补充生物胆碱可降低血尿素（P<0.01），并提高肝酶丙氨酸转氨酶（ALT；P<0.10）和白蛋白水平（P<0.001）。每天超过8克的生物胆碱剂量可提高血糖、白蛋白（P<0.10）、胆固醇、总蛋白和球蛋白水平（P<0.05）。在生长羔羊中，生物胆碱相对于对照组在保留能量方面的ES值为+7.15%NEm（P<0.10）和+9.25%NEg（P<0.10）。总之，在反刍动物日粮中添加生物胆碱粉可提高生产性能、蛋白质代谢的血液代谢物指标和肝脏健康，显示出其营养保健特性，其中磷脂酰胆碱占主导地位，可作为满足反刍动物胆碱需求的一种替代品。
