Sartori M, Henry P D, Sauerbrey R, Tittel F K, Weilbaecher D, Roberts R
Section of Cardiology, Baylor College of Medicine, Rice University, Houston, TX.
Lasers Surg Med. 1987;7(4):300-6. doi: 10.1002/lsm.1900070404.
Ablation rates measured as the depth of tissue excavation per unit time were determined in human and canine aortas subjected to radiation with ultraviolet (UV) excimer (ArF 193 nm, KrF 248 nm, XeF 351 nm) and visible lasers [continuous wave (cw) and 50-ms chopped argon ion, 478 nm-514 nm; pulsed double-frequency Nd:YAG, 532 nm]. For UV and pulsed double-frequency Nd:YAG lasers ablation rates were constant in time and depended linearly on average laser power, but for cw and chopped argon lasers ablation rates varied with irradiation time and were nonlinearly dependent on laser power. In human aortas, atherosclerosis without gross calcification had no influence on ablation rates. Charring and tissue disruption were observed with cw and chopped argon ion, whereas excimer and pulsed Nd:YAG lasers produced only minimal injury to surrounding tissue. We conclude that the determination of ablation rates is useful for the selection of laser wavelengths and power densities applicable to angioplasty and that UV and pulsed visible laser permit a better control of ablation compared to continuous wave lasers.
在接受紫外线（UV）准分子激光（ArF 193纳米、KrF 248纳米、XeF 351纳米）和可见光激光[连续波（cw）和50毫秒斩波氩离子激光，478纳米 - 514纳米；脉冲倍频Nd:YAG激光，532纳米]照射的人体和犬类主动脉中，测定了以单位时间组织切除深度衡量的消融率。对于UV和脉冲倍频Nd:YAG激光，消融率在时间上是恒定的，并且与平均激光功率呈线性关系，但对于连续波和斩波氩离子激光，消融率随照射时间变化，并且与激光功率呈非线性关系。在人体主动脉中，无明显钙化的动脉粥样硬化对消融率没有影响。使用连续波和斩波氩离子激光时观察到了碳化和组织破坏，而准分子激光和脉冲Nd:YAG激光对周围组织仅造成最小程度的损伤。我们得出结论，消融率的测定对于选择适用于血管成形术的激光波长和功率密度是有用的，并且与连续波激光相比，UV和脉冲可见光激光能够更好地控制消融。
