Grundfest W S, Litvack F, Forrester J S, Goldenberg T, Swan H J, Morgenstern L, Fishbein M, McDermid I S, Rider D M, Pacala T J
J Am Coll Cardiol. 1985 Apr;5(4):929-33. doi: 10.1016/s0735-1097(85)80435-6.
Seventy samples of human cadaver atherosclerotic aorta were irradiated in vitro using a 308 nm xenon chloride excimer laser. Energy per pulse, pulse duration and frequency were varied. For comparison, 60 segments were also irradiated with an argon ion and an Nd:YAG (neodymium:yttrium aluminum garnet) laser operated in the continuous mode. Tissue was fixed in formalin, sectioned and examined microscopically. The Nd:YAG and argon ion-irradiated tissue exhibited a central crater with irregular edges and concentric zones of thermal and blast injury. In contrast, the excimer laser-irradiated tissue had narrow deep incisions with minimal or no thermal injury. These preliminary experiments indicate that the excimer laser vaporizes tissue in a manner different from that of the continuous wave Nd:YAG or argon ion laser. The sharp incision margins and minimal damage to adjacent normal tissue suggest that the excimer laser is more desirable for general surgical and intravascular uses than are the conventionally used medical lasers.
使用308纳米氯化氙准分子激光对70份人类尸体动脉粥样硬化主动脉样本进行体外照射。改变每脉冲能量、脉冲持续时间和频率。作为对照，还使用连续模式操作的氩离子激光和Nd:YAG（钕:钇铝石榴石）激光对60个样本段进行照射。将组织固定在福尔马林中，切片并进行显微镜检查。Nd:YAG激光和氩离子激光照射的组织呈现出边缘不规则的中央火山口以及热损伤和爆炸损伤的同心区域。相比之下，准分子激光照射的组织有狭窄的深切口，热损伤极小或没有热损伤。这些初步实验表明，准分子激光汽化组织的方式与连续波Nd:YAG激光或氩离子激光不同。锐利的切口边缘和对相邻正常组织的最小损伤表明，与传统使用的医用激光相比，准分子激光在普通外科手术和血管内应用中更具优势。
