硝苯地平对乙肝表面抗原阳性肝硬化患者肝脏血流动力学无影响。

Lack of effects of nifedipine on hepatic hemodynamics in patients with HBsAg-positive cirrhosis.

作者信息

Lay C S, Tsai Y T, Kong C W, Lee F Y, Lee S D, Lo K J, Chiang B N, Chen K Y

机构信息

Division of Gastroenterology, Veterans General Hospital, Taipei, Taiwan, R.O.C.

出版信息

Liver. 1987 Aug;7(4):223-7. doi: 10.1111/j.1600-0676.1987.tb00347.x.

DOI:10.1111/j.1600-0676.1987.tb00347.x

PMID:3683094

Abstract

The acute effects of Nifedipine on hepatic venous pressure gradient (HVPG) and estimated hepatic blood flow (EHBF) were investigated in six patients with HBsAg-positive cirrhosis and portal hypertension by simultaneous hepatic venous catheterization. The mean arterial pressure significantly decreased by 18% at 1 h after sublingual administration of 10 mg Nifedipine. Significant increases in heart rate (13%) and cardiac output (20%) were also demonstrated in our patients 1 h after administration of Nifedipine. However, there were no significant changes in HVPG and EHBF after Nifedipine. We conclude that in patients with HBsAg-positive cirrhosis who receive Nifedipine, EHBF is maintained despite a substantial change in systemic hemodynamics, and that Nifedipine is not effective in acutely reducing HVPG.

摘要

通过同步肝静脉插管，研究了硝苯地平对6例HBsAg阳性肝硬化和门静脉高压患者肝静脉压力梯度（HVPG）和估计肝血流量（EHBF）的急性影响。舌下含服10 mg硝苯地平后1小时，平均动脉压显著下降18%。服用硝苯地平1小时后，患者心率（13%）和心输出量（20%）也显著增加。然而，硝苯地平给药后HVPG和EHBF无显著变化。我们得出结论，在接受硝苯地平治疗的HBsAg阳性肝硬化患者中，尽管全身血流动力学发生了显著变化，但EHBF仍得以维持，且硝苯地平在急性降低HVPG方面无效。