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单次400赫兹经颅脉冲电流刺激对皮质脊髓和皮质皮质兴奋性及手部灵活性的影响：一项双盲随机对照试验

Effects of a Single Session 400 Hz Transcranial Pulsed Current Stimulation on Corticospinal and Corticocortical Excitability and Hand Dexterity: A Double-Blind RCT.

作者信息

Jaberzadeh Shapour, Malekahmad Mona, Liu Renming, Zoghi Maryam

机构信息

Monash Neuromodulation Research Unit, Department of Physiotherapy, Monash University, Melbourne, Victoria, Australia.

Discipline of Physiotherapy, Federation University, Churchill, Victoria, Australia.

出版信息

Psychophysiology. 2025 Jul;62(7):e70112. doi: 10.1111/psyp.70112.

DOI:10.1111/psyp.70112
PMID:40696723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12284344/
Abstract

The effects of 400 Hz anodal and cathodal transcranial pulsed current stimulation of the primary motor cortex (400 Hz a-tPCS, 400 Hz c-tPCS) on corticospinal excitability (CSE) and corticocortical excitability (CCE) and hand dexterity remain underexplored. This study examined the effects of a single session of 400 Hz a-tPCS, 400 Hz c-tPCS, and sham stimulation on CSE, CCE, and hand dexterity, providing insights for potential clinical applications in motor deficits. In this double-blinded, randomized, counterbalanced crossover trial, 26 healthy young adults completed three experimental sessions: 400 Hz a-tPCS, 400 Hz c-tPCS, and sham stimulation, spaced 48 h apart. Transcranial magnetic stimulation assessed CSE and CCE, while the Purdue Pegboard Test (PPT) evaluated hand dexterity. The results showed polarity-specific effects. A single session of 400 Hz a-tPCS significantly increased CSE and improved hand dexterity, evidenced by faster PPT completion times (p < 0.05). Conversely, 400 Hz c-tPCS reduced CSE but did not influence PPT performance (p > 0.05). Sham stimulation showed no significant changes. These findings suggest that 400 Hz a-tPCS enhances motor excitability and dexterity, while 400 Hz c-tPCS selectively reduces CSE. This study lays a foundation for exploring high-frequency tPCS in clinical motor rehabilitation.

摘要

400赫兹阳极和阴极经颅脉冲电流刺激初级运动皮层（400赫兹阳极经颅脉冲电流刺激、400赫兹阴极经颅脉冲电流刺激）对皮质脊髓兴奋性（CSE）、皮质皮质兴奋性（CCE）和手部灵活性的影响仍未得到充分研究。本研究考察了单次400赫兹阳极经颅脉冲电流刺激、400赫兹阴极经颅脉冲电流刺激和假刺激对CSE、CCE和手部灵活性的影响，为运动功能障碍的潜在临床应用提供见解。在这项双盲、随机、平衡交叉试验中，26名健康年轻成年人完成了三个实验阶段：400赫兹阳极经颅脉冲电流刺激、400赫兹阴极经颅脉冲电流刺激和假刺激，间隔48小时。经颅磁刺激评估CSE和CCE，而普渡钉板试验（PPT）评估手部灵活性。结果显示出极性特异性效应。单次400赫兹阳极经颅脉冲电流刺激显著提高了CSE并改善了手部灵活性，PPT完成时间更快证明了这一点（p<0.05）。相反，400赫兹阴极经颅脉冲电流刺激降低了CSE，但未影响PPT表现（p>0.05）。假刺激没有显著变化。这些发现表明，400赫兹阳极经颅脉冲电流刺激可增强运动兴奋性和灵活性，而400赫兹阴极经颅脉冲电流刺激可选择性降低CSE。本研究为在临床运动康复中探索高频经颅脉冲电流刺激奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/1c1203692150/PSYP-62-e70112-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/4a9a92a91598/PSYP-62-e70112-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/9fbe936b762d/PSYP-62-e70112-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/26bb72a65015/PSYP-62-e70112-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/c82584a0b06e/PSYP-62-e70112-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/3ce4201db5e7/PSYP-62-e70112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/1c1203692150/PSYP-62-e70112-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/4a9a92a91598/PSYP-62-e70112-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/9fbe936b762d/PSYP-62-e70112-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/26bb72a65015/PSYP-62-e70112-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/c82584a0b06e/PSYP-62-e70112-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/3ce4201db5e7/PSYP-62-e70112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/962e/12284344/1c1203692150/PSYP-62-e70112-g001.jpg

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本文引用的文献

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Transcranial pulsed current stimulation: A scoping review of the current literature on scope, nature, underlying mechanisms, and gaps.经颅脉冲电流刺激：当前文献中关于范围、性质、潜在机制和差距的概述性回顾。
Psychophysiology. 2024 Mar;61(3):e14521. doi: 10.1111/psyp.14521. Epub 2024 Jan 10.
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Exploring sensory, motor, and pain responses as potential side or therapeutic effects of sub-2 mA, 400 Hz transcranial pulsed current stimulation.探索感觉、运动和疼痛反应作为亚 2 mA、400 Hz 经颅脉冲电流刺激的潜在副作用或治疗效果。
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Long-Interval Intracortical Inhibition and the Cortical Silent Period in Youth.
青少年的长时程皮质内抑制与皮质静息期
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Local neuronal excitation and global inhibition during epileptic fast ripples in humans.人类癫痫快棘波发放期间局部神经元兴奋和全局抑制。
Brain. 2023 Feb 13;146(2):561-575. doi: 10.1093/brain/awac319.
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The effects of concurrent bilateral anodal tDCS of primary motor cortex and cerebellum on corticospinal excitability: a randomized, double-blind sham-controlled study.双侧初级运动皮层和小脑同步阳极经颅直流电刺激对皮质脊髓兴奋性的影响：一项随机、双盲、假刺激对照研究。
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