Frigerio Francesco, De Marinis Maria, Camardella Francesca, Cantisani Vito, Pinto Alessandro, Bernardi Marco, Lubrano Carla, Gnessi Lucio, Federici Massimo, Donini Lorenzo Maria, Poggiogalle Eleonora
Department of Experimental Medicine, Sapienza University, P.le Aldo Moro 5, 00185 Rome, Italy.
Department of Radiological, Oncological and Pathobiological Sciences, Sapienza University of Rome, 00144 Rome, Italy.
Biomedicines. 2023 Feb 6;11(2):472. doi: 10.3390/biomedicines11020472.
Accumulating evidence supports a connection between sarcopenic obesity (SO) and NAFLD. The extent to which fatty liver contributes to impaired muscle contractility is not yet well established. The aim of our study was to investigate the effect of NAFLD on dynapenia in patients with SO. In this study, 71 non-diabetic subjects (age 55 (7.8) years, BMI 35.2 kg/m (32.6-38.8)) were classified as having SO and non-sarcopenic obesity (NSO). SO patients displayed worse serum lipid profiles, higher body fat, and lower skeletal muscle mass (both total and appendicular) than NSO patients, despite the absence of any significant differences in body weight, glycometabolic parameters, and hepatic steatosis prevalence. A positive correlation between disposition index and muscle quality index (MQI) ( = 0.393, = 0.013) emerged after controlling for menopause and body fat percentage. Based on multiple linear regression analysis, MQI was significantly positively associated with the disposition index (β: 0.059, SE: 0.002, = 0.006) after adjustment for menopause, body fat percentage, and the presence of hepatic steatosis according to the hepatorenal index (HRI). Similar findings emerged when including liver enzyme levels in place of hepatic steatosis. Muscle quality was positively associated with β-cell function corrected for insulin resistance among patients with obesity and sarcopenic obesity, irrespective of the presence of fatty liver disease.
越来越多的证据支持肌肉减少性肥胖（SO）与非酒精性脂肪性肝病（NAFLD）之间存在关联。脂肪肝对肌肉收缩力受损的影响程度尚未明确。我们研究的目的是调查NAFLD对SO患者肌肉功能减退的影响。在本研究中，71名非糖尿病受试者（年龄55（7.8）岁，BMI 35.2 kg/m²（32.6 - 38.8））被分为SO组和非肌肉减少性肥胖（NSO）组。尽管在体重、糖代谢参数和肝脂肪变性患病率方面没有任何显著差异，但SO患者的血脂谱更差、体脂更高，骨骼肌质量（包括总质量和四肢质量）更低。在控制绝经和体脂百分比后，处置指数与肌肉质量指数（MQI）之间出现正相关（r = 0.393，p = 0.013）。基于多元线性回归分析，在根据肝肾指数（HRI）调整绝经、体脂百分比和肝脂肪变性的存在后，MQI与处置指数显著正相关（β：0.059，SE：0.002，p = 0.006）。当用肝酶水平代替肝脂肪变性时，也出现了类似的结果。在肥胖和肌肉减少性肥胖患者中，无论是否存在脂肪性肝病，肌肉质量与校正胰岛素抵抗后的β细胞功能呈正相关。
