Ito Masato, Kato Shin, Saito Makoto, Miyahara Naoyuki, Arai Hirokazu, Namba Fumihiko, Ota Erika, Nakanishi Hidehiko
Department of Pediatrics, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8602, Japan.
Biomedicines. 2023 Feb 14;11(2):553. doi: 10.3390/biomedicines11020553.
Over the years, bronchopulmonary dysplasia (BPD) affects the pulmonary function of infants, resulting in chronic health burdens for infants and their families. The aim of this scoping review was to screen available evidence regarding perinatal risk factors associated with the development and severity of BPD.
The eligibility criteria of the studies were year of publication between 2016 and 2021; setting of a developed country; English or Japanese as the study language; and randomized controlled, cohort, or case-control design. The titles and abstracts of the studies were screened by independent reviewers.
Of 8189 eligible studies, 3 were included for severe BPD and 26 were included for moderate BPD. The risk factors for severe BPD were male sex, iatrogenic preterm birth, maternal hypertensive disorders of pregnancy (HDP), low gestational age, small-for-gestational-age (SGA) birth weight, mechanical ventilation on day 1, and need for patent ductus arteriosus (PDA) management. The risk factors for moderate or severe BPD included male sex, premature rupture of membranes, clinical chorioamnionitis, maternal HDP, SGA birth weight, bubbly/cystic appearance on X-ray, and PDA management.
We identified several risk factors for BPD. We plan to confirm the validity of the new classification using the existing dataset.
多年来，支气管肺发育不良（BPD）影响婴儿的肺功能，给婴儿及其家庭带来慢性健康负担。本范围综述的目的是筛选有关与BPD发生和严重程度相关的围产期危险因素的现有证据。
研究的纳入标准为2016年至2021年发表；在发达国家开展；研究语言为英语或日语；随机对照、队列或病例对照设计。研究的标题和摘要由独立评审员进行筛选。
在8189项符合条件的研究中，3项纳入重度BPD研究，26项纳入中度BPD研究。重度BPD的危险因素为男性、医源性早产、母亲妊娠高血压疾病（HDP）、低胎龄、小于胎龄（SGA）出生体重、出生第1天进行机械通气以及需要进行动脉导管未闭（PDA）管理。中度或重度BPD的危险因素包括男性、胎膜早破、临床绒毛膜羊膜炎、母亲HDP、SGA出生体重、X线显示有气泡/囊性外观以及PDA管理。
我们确定了BPD的几个危险因素。我们计划使用现有数据集确认新分类的有效性。
