Weill Cornell Medicine, New York, NY 10021, USA.
Cells. 2023 Feb 10;12(4):570. doi: 10.3390/cells12040570.
Alveolar macrophages (AM) are long-lived tissue-resident innate immune cells of the airways. AM are key effectors of recognition, initiation, and resolution of the host defense against microbes and play an essential role in mediating host responses to infection. Lipid metabolism in AM can significantly impact cellular function and biology. Dysregulated metabolism contributes to an accumulation of lipids, unfolded protein response induction, and inflammatory cytokine production. Our study was designed to investigate the impact of Ch25h on mediating innate immune responses by macrophages during . Using wild-type and mice, we examined the role of cholesterol metabolism on inflammatory cytokine production and bacterial clearance. Our results demonstrate that Ch25h plays an important role in the initiation and intensity of cytokine and chemokine production in the lung during infection. In the absence of Ch25h, there was enhanced phagocytosis and bacterial clearance. Taken together, our findings demonstrate the important role of Ch25h in modulating host responsiveness to infection.
肺泡巨噬细胞（AM）是气道中长寿的组织驻留固有免疫细胞。AM 是宿主防御微生物的识别、启动和解决的关键效应物，在介导宿主对感染的反应中发挥着重要作用。AM 中的脂质代谢可以显著影响细胞功能和生物学。代谢失调会导致脂质积累、未折叠蛋白反应诱导和炎性细胞因子产生。我们的研究旨在探讨 Ch25h 在 期间通过巨噬细胞介导固有免疫反应的作用。使用野生型和 小鼠，我们研究了胆固醇代谢对炎性细胞因子产生和细菌清除的作用。我们的结果表明，Ch25h 在 感染期间肺中细胞因子和趋化因子产生的起始和强度中发挥重要作用。在缺乏 Ch25h 的情况下，吞噬作用和细菌清除增强。总之，我们的研究结果表明 Ch25h 在调节宿主对 感染的反应性方面起着重要作用。
