School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.
Cells. 2023 Feb 19;12(4):662. doi: 10.3390/cells12040662.
Progress has been made in identifying stem cell aging as a pathological manifestation of a variety of diseases, including obesity. Adipose stem cells (ASCs) play a core role in adipocyte turnover, which maintains tissue homeostasis. Given aberrant lineage determination as a feature of stem cell aging, failure in adipogenesis is a culprit of adipose hypertrophy, resulting in adiposopathy and related complications. In this review, we elucidate how ASC fails in entering adipogenic lineage, with a specific focus on extracellular signaling pathways, epigenetic drift, metabolic reprogramming, and mechanical stretch. Nonetheless, such detrimental alternations can be reversed by guiding ASCs towards adipogenesis. Considering the pathological role of ASC aging in obesity, targeting adipogenesis as an anti-obesity treatment will be a key area of future research, and a strategy to rejuvenate tissue stem cell will be capable of alleviating metabolic syndrome.
在将干细胞衰老识别为多种疾病（包括肥胖症）的病理表现方面已经取得了进展。脂肪干细胞（ASCs）在维持组织内稳态的脂肪细胞更新中起着核心作用。鉴于谱系异常决定是干细胞衰老的特征之一，脂肪生成失败是脂肪肥大的罪魁祸首，导致脂肪病和相关并发症。在这篇综述中，我们阐明了 ASC 如何无法进入脂肪生成谱系，特别关注细胞外信号通路、表观遗传漂移、代谢重编程和机械拉伸。然而，通过引导 ASCs 向脂肪生成分化，可以逆转这些有害的改变。鉴于 ASC 衰老在肥胖中的病理作用，将脂肪生成作为肥胖治疗的靶点将是未来研究的一个关键领域，而使组织干细胞年轻化的策略将能够缓解代谢综合征。
