Zhu Nisha, Zhao Mengxiang, Song Yuxian, Ding Liang, Ni Yanhong
Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing, Jiangsu 210008, PR China.
Genes Dis. 2020 Jul 24;9(1):28-40. doi: 10.1016/j.gendis.2020.07.008. eCollection 2022 Jan.
first identified as an anti-metastasis gene in melanoma, encodes C-terminally amidated peptide products, including kisspeptin-145, kisspeptin-54, kisspeptin-14, kisspeptin-13 and kisspeptin-10. These products are endogenous ligands coupled to G protein-coupled receptor 54 (GPR54)/hOT7T175/AXOR12. To date, the regulatory activities of the KiSS-1/GPR54 system, such as puberty initiation, antitumor metastasis, fertility in adulthood, hypothalamic-pituitary-gonadal axis (HPG axis) feedback, and trophoblast invasion, have been investigated intensively. Accumulating evidence has demonstrated that played a key role in reproduction and served as a promising biomarker relative to the diagnosis, identification of therapeutic targets and prognosis in various carcinomas, while few studies have systematically summarized its subjective factors and concluded the functions of KiSS-1/GPR54 signaling in physiology homeostasis and cancer biology. In this review, we retrospectively summarized the regulators of the KiSS-1/GPR54 system in different animal models and reviewed its functions according to physiological homeostasis regulations and above all, cancer biology, which provided us with a profound understanding of applying the KiSS-1/GPR54 system into medical applications.
最初在黑色素瘤中被鉴定为一种抗转移基因，编码C末端酰胺化的肽产物，包括亲吻素-145、亲吻素-54、亲吻素-14、亲吻素-13和亲吻素-10。这些产物是与G蛋白偶联受体54（GPR54）/hOT7T175/AXOR12偶联的内源性配体。迄今为止，KiSS-1/GPR54系统的调节活性，如青春期启动、抗肿瘤转移、成年期生育能力、下丘脑-垂体-性腺轴（HPG轴）反馈和滋养层细胞侵袭等，已得到深入研究。越来越多的证据表明，它在生殖中起关键作用，并且相对于各种癌症的诊断、治疗靶点的识别和预后而言，是一种有前景的生物标志物，而很少有研究系统地总结其主观因素并归纳KiSS-1/GPR54信号在生理稳态和癌症生物学中的功能。在这篇综述中，我们回顾性总结了不同动物模型中KiSS-1/GPR54系统的调节因子，并根据生理稳态调节，尤其是癌症生物学，综述了其功能，这为我们将KiSS-1/GPR54系统应用于医学领域提供了深刻的理解。
