Ali Doaa G, Abner Erin L, Bahrani Ahmed A, El Khouli Riham, Gold Brian T, Jiang Yang, Wilcock Donna M, Jicha Gregory A
Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, KY 40506, USA.
Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, KY 40506, USA.
Brain Sci. 2023 Jan 28;13(2):218. doi: 10.3390/brainsci13020218.
Co-occurrence of beta amyloid (Aβ) and white matter hyperintensities (WMHs) increase the risk of dementia and both are considered biomarkers of preclinical dementia. Moderation and mediation modeling were used to define the interplay between global and regional Aβ and WMHs measures in relation to executive function (EF) and memory composite scores outcomes at baseline and after approximately 2 years across a sample of 714 clinically normal participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI 2). The moderation regression analysis showed additive effects of Aβ and WMHs over baseline memory and EF scores ( = 0.401 and 0.061, respectively) and synergistic effects over follow-up EF ( < 0.05). Through mediation analysis, the data presented demonstrate that WMHs effects, mediated by global and regional amyloid burden, are responsible for baseline cognitive performance deficits in memory and EF. These findings suggest that Aβ and WMHs contribute to baseline cognition independently while WMHs volumes exert effects on baseline cognitive performance directly and through influences on Aβ accumulation.
β淀粉样蛋白（Aβ）与白质高信号（WMHs）同时出现会增加患痴呆症的风险，二者均被视为临床前痴呆的生物标志物。在来自阿尔茨海默病神经影像倡议（ADNI 2）的714名临床正常参与者样本中，采用调节和中介模型来定义整体和区域Aβ与WMHs测量值之间的相互作用，这些相互作用与基线时以及大约2年后的执行功能（EF）和记忆综合评分结果相关。调节回归分析显示，Aβ和WMHs对基线记忆和EF评分具有累加效应（分别为= 0.401和0.061），对随访EF具有协同效应（<0.05）。通过中介分析，所呈现的数据表明，由整体和区域淀粉样蛋白负荷介导的WMHs效应是记忆和EF基线认知表现缺陷的原因。这些发现表明，Aβ和WMHs独立地影响基线认知，而WMHs体积直接并通过影响Aβ积累对基线认知表现产生作用。
