一种基于黑磷烯和纳米金刚石复合修饰电极的便携式无线智能纳米传感器用于 6,7-二羟基香豆素分析。

A Portable Wireless Intelligent Nanosensor for 6,7-Dihydroxycoumarin Analysis with A Black Phosphorene and Nano-Diamond Nanocomposite-Modified Electrode.

机构信息

Key Laboratory of Functional Materials and Photoelectrochemistry of Haikou, Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.

College of Health Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

出版信息

Biosensors (Basel). 2023 Jan 18;13(2):153. doi: 10.3390/bios13020153.

In this work, a novel portable and wireless intelligent electrochemical nanosensor was developed for the detection of 6,7-dihydroxycoumarin (6,7-DHC) using a modified screen-printed electrode (SPE). Black phosphorene (BP) nanosheets were prepared via exfoliation of black phosphorus nanoplates. The BP nanosheets were then mixed with nano-diamond (ND) to prepare ND@BP nanocomposites using the self-assembly method, achieving high environmental stability. The nanocomposite was characterized by SEM, TEM, Raman, XPS and XRD. The nanocomposite was used for the modification of SPE to improve its electrochemical performances. The nanosensor displayed a wide linear range of 0.01-450.0 μmol/L with a low detection limit of 0.003 μmol/L for 6,7-DHC analysis. The portable and wireless intelligent electrochemical nanosensor was applied to detect 6,7-DHC in real drug samples by the standard addition method with satisfactory recoveries, which extends the application of BP-based nanocomposite for electroanalysis.

在这项工作中，我们开发了一种新型的便携式无线智能电化学纳米传感器，用于使用修饰后的丝网印刷电极（SPE）检测 6,7-二羟基香豆素（6,7-DHC）。黑磷纳米片是通过剥离黑磷纳米片制备的。然后，通过自组装法将 BP 纳米片与纳米金刚石（ND）混合，制备 ND@BP 纳米复合材料，实现了高环境稳定性。通过 SEM、TEM、Raman、XPS 和 XRD 对纳米复合材料进行了表征。将纳米复合材料用于修饰 SPE，以提高其电化学性能。纳米传感器对 6,7-DHC 的分析显示出 0.01-450.0 μmol/L 的宽线性范围和 0.003 μmol/L 的低检测限。通过标准加入法，便携式无线智能电化学纳米传感器应用于实际药物样品中 6,7-DHC 的检测，回收率令人满意，这扩展了基于 BP 的纳米复合材料在电分析中的应用。