Yamaguchi Junko, Kinoshita Kosaku, Nakagawa Katsuhiro, Mizuochi Minori
Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan.
Diagnostics (Basel). 2023 Feb 17;13(4):762. doi: 10.3390/diagnostics13040762.
This study aimed to clarify whether the influence of undernutrition status and the degree of glycemic disorders affected the prognosis of patients with sepsis. A total of 307 adult patients with sepsis were retrospectively enrolled and analyzed. Characteristics, including nutrition status, calculated according to the Controlling Nutritional Status (CONUT) score of survivors and non-survivors, were examined. The independent prognostic factors of these patients with sepsis were extracted using multivariable logistic regression analysis. The CONUT scores in three glycemic categories were compared. Most patients with sepsis (94.8%) in the study had an undernutrition status according to their CONUT scores. High CONUT scores (odds ratio, 1.214; = 0.002), indicating a poor nutritional status, were associated with high mortality. The CONUT scores in the hypoglycemic group were significantly higher than those in other groups with an undernutrition status (vs. hyperglycemic, < 0.001; vs. intermediate glycemic, = 0.006). The undernutrition statuses of patients with sepsis in the study scored using the CONUT were independent predictors of prognostic factors.
本研究旨在阐明营养不足状态及血糖紊乱程度的影响是否会对脓毒症患者的预后产生影响。本研究回顾性纳入并分析了总共307例成年脓毒症患者。根据存活者和非存活者的控制营养状态(CONUT)评分来检查包括营养状态在内的特征。使用多变量逻辑回归分析提取这些脓毒症患者的独立预后因素。比较了三个血糖类别中的CONUT评分。根据CONUT评分,本研究中大多数脓毒症患者(94.8%)存在营养不足状态。CONUT评分高(比值比,1.214;P = 0.002),表明营养状况差,与高死亡率相关。低血糖组的CONUT评分显著高于其他存在营养不足状态的组(与高血糖组相比,P < 0.001;与血糖中等组相比,P = 0.006)。本研究中使用CONUT评分的脓毒症患者的营养不足状态是预后因素的独立预测指标。