Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin 9016, New Zealand.
Department of Oral Diagnostic and Surgical Sciences, Faculty of Dentistry, University of Otago, 310 Great King Street, Dunedin 9016, New Zealand.
Genes (Basel). 2023 Jan 20;14(2):272. doi: 10.3390/genes14020272.
The mechanical properties of cells are important in tissue homeostasis and enable cell growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties are determined to a large extent by the cytoskeleton. The cytoskeleton is a complex and dynamic network composed of microfilaments, intermediate filaments and microtubules. These cellular structures confer both cell shape and mechanical properties. The architecture of the networks formed by the cytoskeleton is regulated by several pathways, a key one being the Rho-kinase/ROCK signaling pathway. This review describes the role of ROCK (Rho-associated coiled-coil forming kinase) and how it mediates effects on the key components of the cytoskeleton that are critical for cell behaviour.
细胞的力学特性对于组织稳态非常重要，使细胞能够生长、分裂、迁移和上皮-间充质转化。力学特性在很大程度上取决于细胞骨架。细胞骨架是由微丝、中间丝和微管组成的复杂而动态的网络。这些细胞结构赋予了细胞形状和力学特性。细胞骨架形成的网络结构受几条途径调节，其中一个关键途径是 Rho-kinase/ROCK 信号通路。本文描述了 ROCK（Rho 相关卷曲螺旋形成激酶）的作用以及它如何介导对细胞行为关键的细胞骨架关键成分的影响。
