University Research Institute of Maternal and Child Health & Precision Medicine, School of Medicine, National and Kapoditrian University of Athens, 115 27 Athens, Greece.
National Cancer Institute, Frederick, MD 21702, USA.
Genes (Basel). 2023 Jan 31;14(2):380. doi: 10.3390/genes14020380.
The precise control of neural crest stem cell delamination, migration and differentiation ensures proper craniofacial and head development. Sox2 shapes the ontogeny of the cranial neural crest to ensure precision of the cell flow in the developing head. Here, we review how Sox2 orchestrates signals that control these complex developmental processes.
神经嵴干细胞的分层、迁移和分化的精确控制确保了颅面和头部的正常发育。Sox2 塑造了颅神经嵴的个体发生，以确保细胞在发育中的头部中的流动的精确性。在这里，我们回顾了 Sox2 如何协调控制这些复杂发育过程的信号。
