Poison Control Center and Teratology Information Center, ASST Papa Giovanni XXIII, 24100 Bergamo, Italy.
Poison Control Center, ASST Papa Giovanni XXIII, 24100 Bergamo, Italy.
Int J Environ Res Public Health. 2023 Feb 9;20(4):3080. doi: 10.3390/ijerph20043080.
Data from the literature show that prolonged-release injectable antipsychotics (LAIs) ensure constant blood drug levels better patient compliance and offer a simpler treatment regimen for both patients and caregivers. This observational-descriptive study aims to detect the possible complications found in newborns of women with bipolar or psychotic disorders and LAI therapy during pregnancy.
This study involved women with psychotic disorders during pregnancy who contacted the Teratology Information Center of Bergamo, Italy between 2016 and 2021 to receive counseling on the possible risks of exposure to LAI therapy. The follow-up procedure was carried out by telephone interview or direct contact with the patient and/or her physician.
In this study, LAI treatment in pregnancy was not associated with an increased risk of malformations. All but one of the children in the sample were born healthy and the mothers maintained psychopathological compensation during pregnancy.
This study showed that, despite the small size of the sample under examination, the administration of LAIs do not compromise the normal intrauterine development of the unborn child and there were no evident major malformations.
文献中的数据表明，长效注射抗精神病药物（LAIs）能更好地保证血液中的药物稳定水平，提高患者依从性，并为患者和护理人员提供更简单的治疗方案。本观察性描述性研究旨在检测在怀孕期间使用 LAI 治疗的双相或精神病障碍女性所生新生儿可能出现的并发症。
本研究纳入了 2016 年至 2021 年期间联系意大利贝加莫 Teratology Information Center 接受关于 LAI 治疗可能暴露风险咨询的患有精神病障碍的孕妇。通过电话访谈或直接与患者及其医生联系进行随访。
本研究中，怀孕期间的 LAI 治疗并未增加畸形风险。样本中除了一个孩子外，其他所有孩子均健康出生，母亲在怀孕期间保持精神病理补偿。
本研究表明，尽管所检查的样本规模较小，但 LAI 的使用并不影响胎儿的正常宫内发育，也没有明显的重大畸形。
