精神障碍女性的流产风险。
Risk of miscarriage in women with psychiatric disorders.
机构信息
Centre for Fertility and Health, Norwegian Institute of Public Health, Norway; MRC Integrative Epidemiology Unit, University of Bristol, UK; and Population Health Sciences, Bristol Medical School, UK.
Nic Waals Institute, Lovisenberg Diaconal Hospital, Norway; Department of Mental Disorders, Norwegian Institute of Public Health, Norway; and MRC Integrative Epidemiology Unit, University of Bristol, UK.
出版信息
Br J Psychiatry. 2021 Sep;219(3):501-506. doi: 10.1192/bjp.2020.259.
BACKGROUND
Some psychiatric disorders have been associated with increased risk of miscarriage. However, there is a lack of studies considering a broader spectrum of psychiatric disorders to clarify the role of common as opposed to independent mechanisms.
AIMS
To examine the risk of miscarriage among women diagnosed with psychiatric conditions.
METHOD
We studied registered pregnancies in Norway between 2010 and 2016 (n = 593 009). The birth registry captures pregnancies ending in gestational week 12 or later, and the patient and general practitioner databases were used to identify miscarriages and induced abortions before 12 gestational weeks. Odds ratios of miscarriage according to 12 psychiatric diagnoses were calculated by logistic regression.
CONCLUSIONS
A wide range of psychiatric disorders were associated with increased risk of miscarriage. The heightened risk of miscarriage among women diagnosed with psychiatric disorders highlights the need for awareness and surveillance of this risk group in antenatal care.
背景
一些精神疾病与流产风险增加有关。然而，缺乏考虑更广泛精神疾病谱的研究，以明确常见与独立机制的作用。
目的
检查诊断为精神疾病的女性发生流产的风险。
方法
我们研究了 2010 年至 2016 年期间挪威的注册妊娠（n=593009）。出生登记册涵盖了妊娠 12 周或之后结束的妊娠，使用患者和全科医生数据库来识别 12 周妊娠之前的流产和人工流产。通过逻辑回归计算 12 种精神疾病诊断的流产比值比。
结论
广泛的精神疾病与流产风险增加有关。诊断为精神疾病的女性流产风险增加，突出了在产前保健中需要对这一风险群体进行意识和监测。
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