Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
The BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA.
Int J Environ Res Public Health. 2023 Feb 10;20(4):3103. doi: 10.3390/ijerph20043103.
Rates of non-alcoholic fatty liver disease (NAFLD) vary dramatically among Hispanic subpopulations, with Mexican-origin (MO) Hispanics experiencing a disproportionate burden. This study examined dietary fatty acid (FA) intake among overweight and obese MO Hispanic adults in the United States (US) and evaluated its association with liver steatosis and fibrosis. Participants (N = 285, MO Hispanic adults) completed 24-h dietary recalls to assess dietary FA exposure. Liver steatosis and fibrosis were estimated using transient elastography (FibroScan). Multiple regression analysis tested relationships between FA intakes and liver steatosis or fibrosis, adjusting for age, sex, body mass index (BMI) and total energy. A total of 51% (n = 145) of participants were suspected to have NAFLD and 20% self-reported a type 2 diabetes diagnosis. No significant association was observed between Linoleic Acid and α-Linolenic Acid (LA:ALA) ratio, or omega-6 to omega-3 (n-6:n-3) ratio and liver steatosis. However, a one-point increase in the LA:ALA ratio resulted in a 1.01% increase in the liver fibrosis scores (95% CI: [1.00, 1.03]; = 0.03), and a one-point increase in the n-6:n-3 ratio resulted in a 1.02% increase in liver fibrosis score (95% CI: [1.01, 1.03]; = 0.01). Further research is needed to determine if modulation of FA intake could reduce NAFLD risk in this high-risk population.
非酒精性脂肪性肝病（NAFLD）在西班牙裔亚群中的发病率差异很大，其中墨西哥裔（MO）西班牙裔人群的负担不成比例。本研究在美国（US）超重和肥胖的 MO 西班牙裔成年人中检查了饮食脂肪酸（FA）的摄入，并评估了其与肝脂肪变性和纤维化的关系。参与者（N=285，MO 西班牙裔成年人）完成了 24 小时饮食回忆，以评估饮食 FA 暴露情况。使用瞬时弹性成像（FibroScan）估计肝脂肪变性和纤维化。多元回归分析测试了 FA 摄入量与肝脂肪变性或纤维化之间的关系，调整了年龄、性别、体重指数（BMI）和总能量。共有 51%（n=145）的参与者被怀疑患有 NAFLD，20%的参与者自我报告患有 2 型糖尿病。Linoleic Acid 和 α-Linolenic Acid（LA：ALA）比值或 omega-6 到 omega-3（n-6：n-3）比值与肝脂肪变性之间没有显著关联。然而，LA：ALA 比值增加一个点，肝纤维化评分增加 1.01%（95%CI：[1.00，1.03]；=0.03），n-6：n-3 比值增加一个点，肝纤维化评分增加 1.02%（95%CI：[1.01，1.03]；=0.01）。需要进一步研究以确定是否可以调节 FA 摄入来降低这种高风险人群的 NAFLD 风险。
