Jo Hyein, Shim Kyeonghee, Jeoung Dooil
Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.
Int J Mol Sci. 2023 Feb 8;24(4):3436. doi: 10.3390/ijms24043436.
Senescence occurs in response to various stimuli. Senescence has attracted attention because of its potential use in anticancer therapy as it plays a tumor-suppressive role. It also promotes tumorigeneses and therapeutic resistance. Since senescence can induce therapeutic resistance, targeting senescence may help to overcome therapeutic resistance. This review provides the mechanisms of senescence induction and the roles of the senescence-associated secretory phenotype (SASP) in various life processes, including therapeutic resistance and tumorigenesis. The SASP exerts pro-tumorigenic or antitumorigenic effects in a context-dependent manner. This review also discusses the roles of autophagy, histone deacetylases (HDACs), and microRNAs in senescence. Many reports have suggested that targeting HDACs or miRNAs could induce senescence, which, in turn, could enhance the effects of current anticancer drugs. This review presents the view that senescence induction is a powerful method of inhibiting cancer cell proliferation.
衰老会因各种刺激而发生。衰老因其在抗癌治疗中的潜在用途而受到关注，因为它具有肿瘤抑制作用。它还会促进肿瘤发生和治疗抗性。由于衰老可诱导治疗抗性，靶向衰老可能有助于克服治疗抗性。本综述阐述了衰老诱导的机制以及衰老相关分泌表型（SASP）在包括治疗抗性和肿瘤发生在内的各种生命过程中的作用。SASP以一种依赖于环境的方式发挥促肿瘤或抗肿瘤作用。本综述还讨论了自噬、组蛋白去乙酰化酶（HDAC）和微小RNA在衰老中的作用。许多报告表明，靶向HDAC或微小RNA可诱导衰老，进而增强当前抗癌药物的疗效。本综述提出观点，即诱导衰老乃是抑制癌细胞增殖的一种有效方法。
