Sáez-Briones Patricio, Palma Boris, Burgos Héctor, Barra Rafael, Hernández Alejandro
Laboratorio de Neurofarmacología y Comportamiento, Facultad de Ciencias Médicas, Escuela de Medicina, Universidad de Santiago de Chile, Santiago 9170022, Chile.
Facultad de Ciencias Sociales y Humanidades, Escuela de Psicología, Universidad Autónoma de Chile, Santiago 7500912, Chile.
Int J Mol Sci. 2023 Feb 13;24(4):3724. doi: 10.3390/ijms24043724.
It has recently been demonstrated that aromatic bromination at C(2) abolishes all typical psychomotor, and some key prosocial effects of the entactogen MDMA in rats. Nevertheless, the influence of aromatic bromination on MDMA-like effects on higher cognitive functions remains unexplored. In the present work, the effects of MDMA and its brominated analog 2Br-4,5-MDMA (1 mg/kg and 10 mg/kg i.p. each) on visuospatial learning, using a radial, octagonal Olton maze (4 × 4) which may discriminate between short-term and long-term memory, were compared with their influence on in vivo long-term potentiation (LTP) in the prefrontal cortex in rats. The results obtained indicate that MDMA diminishes both short- and long-term visuospatial memory but increases LTP. In contrast, 2Br-4,5-MDMA preserves long-term visuospatial memory and slightly accelerates the occurrence of short-term memory compared to controls, but increases LTP, like MDMA. Taken together, these data are consistent with the notion that the modulatory effects induced by the aromatic bromination of the MDMA template, which abolishes typical entactogenic-like responses, might be extended to those effects affecting higher cognitive functions, such as visuospatial learning. This effect seems not to be associated with the increase of LTP in the prefrontal cortex.
最近有研究表明，在大鼠体内，MDMA分子C(2)位的芳环溴化会消除其所有典型的精神运动效应以及一些关键的亲社会效应。然而，芳环溴化对MDMA类似物在更高认知功能方面的影响仍未得到探索。在本研究中，使用一种可区分短期和长期记忆的放射状八角形奥尔顿迷宫（4×4），比较了MDMA及其溴化类似物2Br - 4,5 - MDMA（均腹腔注射，剂量分别为1mg/kg和10mg/kg）对视觉空间学习的影响，以及它们对大鼠前额叶皮质体内长期增强效应（LTP）的影响。结果表明，MDMA会损害短期和长期视觉空间记忆，但会增强LTP。相比之下，与对照组相比，2Br - 4,5 - MDMA能保留长期视觉空间记忆，并略微加速短期记忆的形成，但与MDMA一样，也会增强LTP。综上所述，这些数据与以下观点一致：MDMA模板的芳环溴化所诱导的调节效应，虽然消除了典型的致幻剂样反应，但可能会扩展到影响更高认知功能的效应，如视觉空间学习。这种效应似乎与前额叶皮质中LTP的增加无关。
