口腔过敏性接触性黏膜炎在金属过敏镍致敏耳模型中的交叉反应性。
Cross-Reactivity of Intraoral Allergic Contact Mucositis in the Nickel-Sensitized Ear Model of Metal Allergy.
机构信息
Department of Oral and Maxillofacial Surgery, Sendai Tokushukai Hospital, Sendai 981-3116, Japan.
Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, Sagamihara 252-0392, Japan.
出版信息
Int J Mol Sci. 2023 Feb 16;24(4):3965. doi: 10.3390/ijms24043965.
Cross-reactivity of metal allergies can make metal allergy treatment complicated because the background of immune response in cross-reactions remains unknown. In clinical settings, cross-reactivity among several metals has been suspected. However, the precise mechanism of immune response in cross-reactivity is unclear. Two sensitizations with nickel, palladium, and chromium plus lipopolysaccharide solution into the postauricular skin were followed by a single nickel, palladium, and chromium challenge of the oral mucosa to generate the intraoral metal contact allergy mouse model. Results showed that the infiltrating T cells in nickel-sensitized, palladium- or chromium-challenged mice expressed CD8+ cells, cytotoxic granules, and inflammation-related cytokines. Thus, nickel ear sensitization can cause cross-reactive intraoral metal allergy.
金属过敏的交叉反应使得金属过敏的治疗变得复杂，因为交叉反应中免疫反应的背景尚不清楚。在临床环境中，已经怀疑几种金属之间存在交叉反应。然而，交叉反应中免疫反应的确切机制尚不清楚。用镍、钯和铬加上脂多糖溶液对耳后皮肤进行两次致敏，然后用单一的镍、钯和铬对口腔粘膜进行一次挑战，以产生口腔金属接触过敏的小鼠模型。结果表明，在镍致敏、钯或铬 challenged 的小鼠中浸润的 T 细胞表达 CD8+细胞、细胞毒性颗粒和炎症相关细胞因子。因此，镍耳致敏可引起交叉反应性口腔金属过敏。
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