Metals Are Important Contact Sensitizers: An Experience from Lithuania.

Metals are very frequent sensitizers causing contact allergy and allergic contact dermatitis worldwide; up-to-date data based on patch test results has proved useful for the identification of a problem. In this retrospective study prevalence of contact allergy to metals (nickel, chromium, palladium, gold, cobalt, and titanium) in Lithuania is analysed. Clinical and patch test data of 546 patients patch tested in 2014-2016, in Vilnius University Hospital Santariskiu Klinikos, was analysed and compared with previously published data. Almost third of tested patients (29.56%) were sensitized to nickel. Younger women were more often sensitized to nickel than older ones (36% versus 22.8%, = 0.0011). Women were significantly more often sensitized to nickel than men (33% versus 6.1%, < 0.0001). Younger patients were more often sensitized to cobalt (11.6% versus 5.7%, = 0.0183). Sensitization to cobalt was related to sensitization to nickel ( < 0.0001). Face dermatitis and oral discomfort were related to gold allergy (28% versus 6.9% dermatitis of other parts, < 0.0001). Older patients were patch test positive to gold(I) sodium thiosulfate statistically significantly more often than younger ones (44.44% versus 21.21%, = 0.0281). Nickel, gold, cobalt, and chromium are leading metal sensitizers in Lithuania. Cobalt sensitization is often accompanied by sensitization to nickel. Sensitivity rate to palladium and nickel indicates possible cross-reactivity. No sensitization to titanium was found.