Nagai Norihiro, Mushiga Yasuaki, Ozawa Yoko
Department of Ophthalmology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo 104-8560, Japan.
Laboratory of Retinal Cell Biology, St. Luke's International University, 9-1 Akashi-cho, Chuo-ku, Tokyo 104-8560, Japan.
J Clin Med. 2023 Feb 8;12(4):1360. doi: 10.3390/jcm12041360.
Choriocapillaris flow deficits detected on optical coherence tomography angiographs were retrospectively analyzed. In 38 age-related macular degeneration (AMD) fellow eyes, without fundus findings (26 men, 71.7 ± 1.9 years old), and 22 control eyes (11 men, 69.4 ± 1.8), the choriocapillaris flow area (CCFA) ratio and coefficient of variation (CV) of the CCFA ratio (which represented the heterogeneity of the ratio), negatively and positively correlated with age (all < 0.01), respectively. Moreover, the respective mean values were lower ( = 0.0031) and greater ( = 0.002) in AMD fellow eyes than in the control eyes. The high-risk condition of AMD fellow eyes was defined by a CCFA ratio <58.5%, and the CV of the CCFA ratio ≥0.165 (odds ratio (OR), 5.408; 95% confidence interval (CI): 1.117-21.118, = 0.035, after adjusting for age and sex) was related to the presence of fundus autofluorescence abnormality (OR, 16.440; 95% CI, 1.262-214.240; = 0.033) and asymmetrically dilated choroidal large vasculature (OR, 4.176; 95% CI, 1.057-16.503; = 0.042), after adjusting for age and sex. The presence of fundus autofluorescence abnormality indicated a retinal pigment epithelium (RPE) abnormality. The RPE volume was reduced in the latter eye group, particularly in the thinner choroidal vasculature. In addition to aging, RPE abnormality and choroidal large vascular flow imbalances were associated with exacerbated heterogeneous choriocapillaris flow deficits in AMD fellow eyes without macular neovascularization.
对光学相干断层扫描血管造影检测到的脉络膜毛细血管血流缺损进行回顾性分析。在38只年龄相关性黄斑变性（AMD）对侧眼（无眼底病变，26名男性，71.7±1.9岁）和22只对照眼（11名男性，69.4±1.8岁）中，脉络膜毛细血管血流面积（CCFA）比值和CCFA比值的变异系数（CV）（代表比值的异质性）分别与年龄呈负相关和正相关（均<0.01）。此外，AMD对侧眼的各自平均值低于（=0.0031）对照眼，而CV高于（=0.002）对照眼。AMD对侧眼的高危情况定义为CCFA比值<58.5%，且CCFA比值的CV≥0.165（优势比（OR），5.408；95%置信区间（CI）：1.117 - 21.118，=0.035，在调整年龄和性别后）与眼底自发荧光异常的存在相关（OR，16.440；95%CI，1.262 - 214.240；=0.033）以及脉络膜大血管不对称扩张相关（OR，4.176；95%CI，1.057 - 16.503；=0.042），在调整年龄和性别后。眼底自发荧光异常的存在表明视网膜色素上皮（RPE）异常。在后一组眼中，RPE体积减少，尤其是在脉络膜血管较薄的区域。除衰老外，RPE异常和脉络膜大血管血流失衡与无黄斑新生血管形成的AMD对侧眼中脉络膜毛细血管血流缺损的异质性加剧有关。
