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经尿道膀胱颈切开术联合或不联合其他手术可恢复女性排尿功能障碍患者的自主排尿——一项长期回顾性随访研究

Transurethral Incision of the Bladder Neck with or without Additional Procedure Resumes Spontaneous Voiding in Female Voiding Dysfunction-A Long-Term Retrospective Follow-Up.

作者信息

Ong Hueih-Ling, Kuo Hann-Chorng

机构信息

Department of Urology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi 622, Taiwan.

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970, Taiwan.

出版信息

J Clin Med. 2023 Feb 14;12(4):1514. doi: 10.3390/jcm12041514.

Abstract

AIM

This study evaluated the long-term effectiveness of transurethral incision of the bladder neck (TUI-BN) with or without an additional procedure for female voiding dysfunction.

METHODS

Women with voiding difficulty who underwent TUI-BN in the last 12 years were included. All patients underwent a videourodynamics study (VUDS) at baseline and after TUI-BN. A successful outcome was defined as having a voiding efficiency (VE) increase by ≥50% after treatment. Patients with insufficient improvement were chosen for repeated TUI-BN, urethral onabotulinumtoxinA injection, or transurethral external sphincter incision (TUI-ES). The current voiding status, surgical complications, and additional surgeries were evaluated.

RESULTS

A total of 102 women with VUDS evidence of a narrow bladder neck during voiding were enrolled. The long-term success rate of the first TUI-BN was 29.4% (30/102) and increased to 66.7% (34/51) after combining TUI-BN and an additional procedure. The overall long-term success rates were 74.6% in women with detrusor underactivity (DU), 52.0% in detrusor overactivity and low contractility, 50.0% in bladder neck obstruction, 20.0% in hypersensitive bladder, and 75% in stable bladder ( = 0.022). Patients with a lower maximum flow rate (Qmax), ( = 0.002), lower voided volume ( < 0.001), lower corrected Qmax ( < 0.001), lower ladder contractility index ( = 0.003), lower voiding efficiency ( < 0.001), but larger post-void residual volume ( < 0.001) had a satisfactory surgical outcome. Spontaneous voiding was achieved in 66 (64.7%) patients, de novo urinary incontinence in 21 (20.6%), and vesicovaginal fistula in 4 (3.9%), all were repaired.

CONCLUSIONS

TUI-BN alone or in combination with an additional procedure was safe, effective, and durable in patients with DU to resume spontaneous voiding.

摘要

目的

本研究评估了经尿道膀胱颈切开术(TUI-BN)单独或联合其他手术治疗女性排尿功能障碍的长期疗效。

方法

纳入过去12年内接受TUI-BN治疗的排尿困难女性。所有患者在基线时和TUI-BN术后均接受了视频尿动力学检查(VUDS)。成功的结果定义为治疗后排尿效率(VE)提高≥50%。改善不足的患者被选择进行重复TUI-BN、尿道注射肉毒杆菌毒素A或经尿道外括约肌切开术(TUI-ES)。评估了当前的排尿状态、手术并发症和额外的手术情况。

结果

共有102名在VUDS检查中有排尿时膀胱颈狭窄证据的女性入组。首次TUI-BN的长期成功率为29.4%(30/102),联合TUI-BN和其他手术治疗后成功率提高到66.7%(34/51)。逼尿肌活动低下(DU)女性的总体长期成功率为74.6%,逼尿肌活动亢进伴低收缩力女性为52.0%,膀胱颈梗阻女性为50.0%,膀胱过敏女性为20.0%,稳定膀胱女性为75%(P = 0.022)。最大尿流率(Qmax)较低(P = 0.002)、排尿量较低(P < 0.001)、校正后Qmax较低(P < 0.001)、阶梯收缩指数较低(P = 0.003)、排尿效率较低(P < 0.001)但残余尿量较大(P < 0.001)的患者手术效果良好。66例(64.7%)患者实现了自主排尿,21例(20.6%)出现了新发尿失禁,4例(3.9%)出现了膀胱阴道瘘,所有瘘口均得到修复。

结论

TUI-BN单独或联合其他手术治疗对DU患者恢复自主排尿是安全、有效且持久的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1a7/9964962/76c47865bfb1/jcm-12-01514-g001.jpg

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