Juszczak Kajetan, Drewa Tomasz
Department of Urology, Memorial Rydygier Hospital, Kraków, Poland.
Department of Urology, Nicolaus Copernicus University, Bydgoszcz, Poland; Department of General and Oncological Urology, Nicolaus Copernicus Hospital, Toruń, Poland.
Pharmacol Rep. 2016 Aug;68(4):703-6. doi: 10.1016/j.pharep.2016.03.007. Epub 2016 Mar 19.
Higher incidence of functional urinary bladder dysfunction (detrusor overactivity - DO and detrusor underactivity - DU) occurs in elderly people. Effective therapy is widely used in patients with DO, in contrast DU seems to be a serious burden for the older population due to the lack of successful treatment. The aim of the study was to review the potential pharmacological targets in DU treatment in the animal model. This review is based on systemic literature research. The Medline/Pubmed, Scopus, Embase, and Web of Science databases were searched in order to identify original and review articles, as well as editorials relating to underactive bladder, detrusor underactivity. The following Medical Subject Headings (MeSH) terms were used to ensure the sensitivity of the searches: urinary bladder, animal models, humans and therapy. 19 papers met the criteria and were included for this review. 19 papers met the criteria and were included for this review. The pathophysiology of DU and its animal models were described. Moreover, the potential pharmacological targets in DU therapy were discussed, such as bombesin receptors, prostaglandin-, ATP-, NO-, CGRP-, SP-, Dopamine-, NGF-, M2-, and agrin-dependent pathways. In conclusion, due to the lack of effective treatment strategies in DU, further research is necessary. Close cooperation between urologists and pharmacologists should be maintained for optimal research on DU pharmacotherapy.
功能性膀胱功能障碍（逼尿肌过度活动症 - DO和逼尿肌活动不足 - DU）在老年人中发病率更高。DO患者广泛使用有效治疗方法，相比之下，由于缺乏成功的治疗方法，DU似乎给老年人群带来了沉重负担。本研究的目的是回顾动物模型中DU治疗的潜在药理学靶点。本综述基于系统的文献研究。检索了Medline/Pubmed、Scopus、Embase和Web of Science数据库，以识别与膀胱活动不足、逼尿肌活动不足相关的原创文章、综述文章以及社论。使用了以下医学主题词（MeSH）来确保检索的敏感性：膀胱、动物模型、人类和治疗。19篇论文符合标准并被纳入本综述。描述了DU及其动物模型的病理生理学。此外，还讨论了DU治疗中的潜在药理学靶点，如蛙皮素受体、前列腺素、ATP、NO、降钙素基因相关肽、P物质、多巴胺、神经生长因子、M2和聚集蛋白依赖性途径。总之，由于DU缺乏有效的治疗策略，有必要进行进一步研究。泌尿科医生和药理学家之间应保持密切合作，以优化DU药物治疗的研究。
