膳食纤维摄入量影响强直性脊柱炎疾病状态的变化。
Dietary Fiber Intake Influences Changes in Ankylosing Spondylitis Disease Status.
作者信息
Song Chuan, Wang Lei, Ji Xiaojian, Wang Yiwen, Hu Lidong, Liu Xingkang, Zhang Jiaxin, Liao Simin, Yan Yishu, Zhu Jian, Huang Feng
机构信息
Department of Rheumatology and Immunology, The First Medical Center, Chinese PLA General Hospital, Beijing 100039, China.
Medical School of Chinese PLA, Beijing 100039, China.
出版信息
J Clin Med. 2023 Feb 17;12(4):1621. doi: 10.3390/jcm12041621.
The objectives of this study were to characterize dietary fiber (DF) intake in patients with ankylosing spondylitis (AS), to assess whether DF intake affects disease activity in AS, and to investigate the effect of DF intake on disease activity in AS in the context of functional bowel disease (FBD) symptoms. We recruited 165 patients with AS and divided them into two groups according to whether they had a high DF intake > 25 g/d to investigate the characteristics of people with high DF intake. Some 72 of the 165 AS patients (43%) met the criteria for high DF intake, which was more common in patients with negative FBD symptoms (68%). Data analysis revealed that DF intake was negatively associated with AS disease activity and did not differ statistically significantly from FBD symptoms. Multivariate adjusted models were used to explore the effect of DF intake on AS disease activity. ASDAS-CRP and BASDAI were stable and negatively correlated across models in both groups with and without FBD symptoms. Thus, DF intake positively affected disease activity in patients with AS. ASDAS-CRP and BASDAI were negatively correlated with DF intake.
本研究的目的是描述强直性脊柱炎（AS）患者的膳食纤维（DF）摄入量，评估DF摄入量是否影响AS的疾病活动，并在功能性肠病（FBD）症状的背景下研究DF摄入量对AS疾病活动的影响。我们招募了165例AS患者，并根据他们的DF摄入量是否>25 g/d将他们分为两组，以研究高DF摄入量人群的特征。165例AS患者中约72例（43%）符合高DF摄入量标准，这在FBD症状阴性的患者中更为常见（68%）。数据分析显示，DF摄入量与AS疾病活动呈负相关，且与FBD症状在统计学上无显著差异。使用多变量调整模型来探讨DF摄入量对AS疾病活动的影响。在有和没有FBD症状的两组中，ASDAS-CRP和BASDAI在各模型中均稳定且呈负相关。因此，DF摄入量对AS患者的疾病活动有积极影响。ASDAS-CRP和BASDAI与DF摄入量呈负相关。
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