Cheng Hongyu, Guan Xiong, Chen Dekun, Ma Wentao
Veterinary Immunology Laboratory, College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling 712100, China.
Microorganisms. 2019 Nov 20;7(12):583. doi: 10.3390/microorganisms7120583.
The intestinal tract of vertebrates is normally colonized with a remarkable number of commensal microorganisms that are collectively referred to as gut microbiota. Gut microbiota has been demonstrated to interact with immune cells and to modulate specific signaling pathways involving both innate and adaptive immune processes. Accumulated evidence suggests that the imbalance of Th17 and Treg cells is associated with the development of many diseases. Herein, we emphatically present recent findings to show how specific gut microbiota organisms and metabolites shape the balance of Th17 and Treg cells. We also discuss the therapeutic potential of fecal microbiota transplantation (FMT) in diseases caused by the imbalance of Th17 and Treg cells.
脊椎动物的肠道通常定殖有大量的共生微生物，这些微生物统称为肠道微生物群。肠道微生物群已被证明可与免疫细胞相互作用，并调节涉及先天性和适应性免疫过程的特定信号通路。越来越多的证据表明，Th17细胞和调节性T细胞（Treg）的失衡与许多疾病的发生发展有关。在此，我们着重介绍最近的研究结果，以展示特定的肠道微生物群及其代谢产物如何塑造Th17细胞和Treg细胞的平衡。我们还讨论了粪便微生物群移植（FMT）在由Th17细胞和Treg细胞失衡引起的疾病中的治疗潜力。
